Results 11 to 20 of about 6,115 (211)

Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats.

open access: yesPLoS ONE, 2014
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 should be paid more attention because baicalin was used widely. The aim of this
Na Gao   +6 more
doaj   +2 more sources

Analysis of umbilical cord tissue as an indicator of in utero exposure to toxic adulterating substances

open access: yesFrontiers in Pediatrics, 2023
In utero drug exposure is a significant public health threat to the well-being and normal development of the neonate. Recently, testing of umbilical cord tissue (UCT) has been employed to measure illicit drug exposure, as drugs used by the mother during ...
Kari M. Midthun   +5 more
doaj   +1 more source

Solubility Characteristics of Acetaminophen and Phenacetin in Binary Mixtures of Aqueous Organic Solvents: Experimental and Deep Machine Learning Screening of Green Dissolution Media

open access: yesPharmaceutics, 2022
The solubility of active pharmaceutical ingredients is a mandatory physicochemical characteristic in pharmaceutical practice. However, the number of potential solvents and their mixtures prevents direct measurements of all possible combinations for ...
Piotr Cysewski   +4 more
doaj   +1 more source

Anti-Tumoral and Anti-Angiogenic Effects of Low-Diluted Phenacetinum on Melanoma

open access: yesFrontiers in Oncology, 2021
Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. If primary cutaneous melanoma is mostly treated with a curative wide local excision, malignant melanoma has a poor prognosis and ...
Camille Fuselier   +10 more
doaj   +1 more source

Potential application of thermo-sensitive hydrogels for controlled release of phenacetin [PDF]

open access: yesHemijska Industrija, 2012
Over the past years, many scientific researches have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer.
Ilić-Stojanović Snežana S.   +6 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

EFFECT OF CERTAIN ADDITIVES ON THE DIFFUSION CHARACTERISTICS OF ASPIRIN, SALICYLAMIDE AND PHENACETIN THROUGH A CELLOPHANE MEMBRANE II. Effect of Aliphatic Acids and Polyethylene Glycol [PDF]

open access: yesBulletin of Pharmaceutical Sciences. Assiut University, 1984
 A study has been carried out showing the effect of succinic, citric and tartaric acids, polyethylene glycols 1500, 2000, 4000 and 6000 on the diffusion rate of aspirin, salicylamide and phenacetin through a standard cellophane membrane.
S. Mohamed, H. El-Sourady, F. Habib
doaj   +1 more source

Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

open access: yesHeliyon, 2022
Context: Direct evidence of Triphala-drug interactions has not been provided to date. Objective: This study was aimed to determine the effects of Triphala on cytochrome P450 (CYP) isoforms and P-glycoprotein (P-gp) in vitro, and to investigate ...
Jannarin Nontakham   +7 more
doaj   +1 more source

Analytical Method Development of Benzisothiazolinone, a Biocide, Using LC–MS/MS and a Pharmacokinetic Application in Rat Biological Matrices

open access: yesMolecules, 2023
Benzisothiazolinone (BIT), a biocide widely used as a preservative in household cleaning and personal care products, is cytotoxic to lung cells and a known skin allergen in humans, which highlights the importance of assessing its toxicity and ...
Seong Jun Jo   +5 more
doaj   +1 more source

Optimization of the CYP inhibition assay using LC-MS/MS

open access: yesMethodsX, 2022
The data presented in this article are related to the research article entitled “Cytochrome P450 inhibition activities of non-standardized botanical products” [1], in which the possible CYP inhibitory properties of botanical products were investigated ...
Muhammad Asyraf Abduraman   +4 more
doaj   +1 more source

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