Results 11 to 20 of about 6,598 (209)

Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin [PDF]

Journal of Advanced Pharmaceutical Technology & Research, 2016
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 ...
Alexander V Gerasimov, Mikhail A Varfolomeev, Marat A Ziganshin, Valery V Gorbatchuk, Il′naz T Rakipov, Alexander E Klimovitskii, Liana S Usmanova   +6 more
doaj   +3 more sources

The ban on phenacetin is associated with changes in the incidence trends of upper‐urinary tract cancers in Australia

Australian and New Zealand Journal of Public Health, 2014
Background: Phenacetin is an analgesic that causes renal diseases and cancers of the upper‐urinary tract (UUT). It was banned in most countries from the late 1960s.
Sebastien Antoni, Isabelle Soerjomataram, Suzanne Moore, Jacques Ferlay, Freddy Sitas, David P. Smith, David Forman   +6 more
doaj   +3 more sources

Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo

Molecules, 2018
Honokiol (2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol) and magnolol (4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol) are the major active polyphenol constituents of Magnolia officinalis (Magnoliaceae) bark, which has been widely used in ...
Sang-Bum Kim, Kyu-Sang Kim, Heon-Min Ryu, Seong-Ho Hong, Bo-Kyoung Kim, Dae-Duk Kim, Jin Woo Park, In-Soo Yoon   +7 more
doaj   +2 more sources

Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats.

PLoS ONE, 2014
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 should be paid more attention because baicalin was used widely. The aim of this
Na Gao, Bing Qi, Fang-jun Liu, Yan Fang, Jun Zhou, Lin-jing Jia, Hai-ling Qiao   +6 more
doaj   +2 more sources

PharmVar GeneFocus: CYP1A2-Clinical Impact, Genetic Variation, and Updated Nomenclature. [PDF]

Clin Pharmacol Ther
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Monostory K, Villapalos Garcia G, Koller D, Adams S, Bousman CA, Tsermpini EE, Whirl-Carrillo M, Turner AJ, Lauschke VM, Nagy M, Boone EC, Klein TE, Zubiaur P, Gaedigk A.   +13 more
europepmc   +2 more sources

Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Pharmacovigilance has revealed an alarming correlation between certain medications and a higher risk of cancer. In this narrative review, included research from 2020 to 2025, along with a few seminal older studies, so that it provides a clear picture of which drugs actually set off cancer and mechanisms involved at the molecular ...
Seyoum Tadesse D, Tekletsadik K, Begashaw B, Shewasinad Yehualashet A, Mekonnen Ali A, Ayenew KD.   +5 more
europepmc   +2 more sources

EFFECT OF CERTAIN ADDITIVES ON THE DIFFUSION CHARACTERISTICS OF ASPIRIN, SALICYLAMIDE AND PHENACETIN THROUGH A CELLOPHANE MEMBRANE II. Effect of Aliphatic Acids and Polyethylene Glycol [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1984
 A study has been carried out showing the effect of succinic, citric and tartaric acids, polyethylene glycols 1500, 2000, 4000 and 6000 on the diffusion rate of aspirin, salicylamide and phenacetin through a standard cellophane membrane.
S. Mohamed, H. El-Sourady, F. Habib
doaj   +1 more source

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +2 more sources

Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

Heliyon, 2022
Context: Direct evidence of Triphala-drug interactions has not been provided to date. Objective: This study was aimed to determine the effects of Triphala on cytochrome P450 (CYP) isoforms and P-glycoprotein (P-gp) in vitro, and to investigate ...
Jannarin Nontakham, Pongpun Siripong, Hitoshi Sato, Savita Chewchinda, Kuntarat Arunrungvichian, Jantana Yahuafai, Arman Syah Goli, Vilasinee Hirunpanich Sato   +7 more
doaj   +1 more source

Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report. [PDF]

Pharmacotherapy
ABSTRACT Background Drug interactions involving immunosuppressants can compromise transplant outcomes. Although repeated ketamine administration induces hepatic enzymes in experimental models, clinical reports of induced clearance of cytochrome P450 (CYP) substrates are lacking. Continuous subcutaneous ketamine infusions are increasingly used for acute
Stojanova J, Murnion B, Burrows F, Carlos L, Mizuno T, Nadai T, Irie K, Helsby N, Muthiah K, Day R.   +9 more
europepmc   +2 more sources