Results 31 to 40 of about 11,244 (259)

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

Journal of Advanced Pharmaceutical Technology & Research, 2017
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery
Liana Stanislavovna Usmanova, Marat Akhmedovich Ziganshin, Valery Vilenovich Gorbatchuk, Sufia Askhatovna Ziganshina, Dmitry Anatolevich Bizyaev, Anastas Akhmetovich Bukharaev, Timur Anvarovich Mukhametzyanov, Alexander Vladimirovich Gerasimov   +7 more
doaj   +1 more source

Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats.

PLoS ONE, 2014
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 should be paid more attention because baicalin was used widely. The aim of this
Na Gao, Bing Qi, Fang-jun Liu, Yan Fang, Jun Zhou, Lin-jing Jia, Hai-ling Qiao   +6 more
doaj   +1 more source

N-(4-Ethoxy-2,5-dinitrophenyl)acetamide

IUCrData, 2020
In the title compound, C10H11N3O6, the torsion angles about the bonds to the benzene ring are less than 4°, except for the nitro groups, which are twisted out of the ring plane by 25.27 (3) and 43.63 (2)°.
Sannihith N. Uppu, Ogad A. Agu, Curtistine J. Deere, Frank R. Fronczek   +3 more
doaj   +1 more source

Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method

Frontiers in Pharmacology, 2021
Poziotinib is an orally active, irreversible, pan-HER tyrosine kinase inhibitor used to treat non-small cell lung cancer, breast cancer, and gastric cancer.
Jinhui Wang, Feifei Chen, Hui Jiang, Jia Xu, Deru Meng, Peiwu Geng, Dapeng Dai, Jingbo Hu, Yunfang Zhou, Quan Zhou, Shuanghu Wang   +10 more
doaj   +1 more source

Personal Doses of Cocaine and Coca Paste are Adulterated in Cartagena de Indias (Colombia)

The Scientific World Journal, 2021
Knowledge of drug composition consumed on the streets and the identification and quantification of their adulterants is essential for understanding unexpected side effects, tracking routes, and drug profiling.
Jefferson Urzola-Ortega, Luis Mendoza-Goez, Diofanor Acevedo   +2 more
doaj   +1 more source

Insights into the Adsorption Performance of Emerging Contaminants on Granular Activated Carbon

Separations, 2023
Emerging contaminants are being detected at a high frequency, posing significant environmental and human health challenges. This study aimed to investigate the potential of using commercial granular activated carbon for adsorbing nine aqueous emerging ...
Sang-Hoon Lee, Namgyu Kim, Donghee Park
doaj   +1 more source

Physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin

Results in Chemistry
Substituting hydrogen atoms with fluorine alters physicochemical properties often resulting in improved drug action relative to the parent molecule. The high electronegativity of fluorine changes the electron density distribution of the molecule; however,
Hannah L. Cure, Thomas A. Shell
doaj   +1 more source

Case-control study on analgesics and nephropathy (SAN): protocol

BMC Nephrology, 2005
Background The association between intake of non-phenacetin-containing analgesics and the occurrence of chronic renal failure is still controversially discussed. A new epidemiologic study was planned and conducted in Germany and Austria.
van der Woude Fokko, Lewis Michael, Garbe Edeltraut, Heinemann Lothar AJ, Graf Helmut   +4 more
doaj   +1 more source

Treading the fine white line: cocaine trafficking [PDF]

, 2016
The illicit drug’s trade is a highly profitable business that grasps the interest of millions of people and equally affects millions of others. Cocaine is a highly addictive drug that plagues many countries.
McNicholl, S, O'Hagan, A
core   +1 more source

N-(4-Methoxy-3-nitrophenyl)acetamide

IUCrData, 2023
The title compound, C9H10N2O4, crystallizes with a disordered nitro group in twinned crystals. Both the methoxy group and the acetamide groups are nearly coplanar with the phenyl ring, and the C—N—C—O torsion angle [0.2 (4)°] is also insignificantly ...
James E. Hines III, Ogad A. Agu, Curtistine J. Deere, Frank R. Fronczek, Rao M. Uppu   +4 more
doaj   +1 more source