Results 51 to 60 of about 11,244 (259)

Analgesics use and ESRD in younger age: a case-control study

BMC Nephrology, 2007
Background An ad hoc peer-review committee was jointly appointed by Drug Authorities and Industry in Germany, Austria and Switzerland in 1999/2000 to review the evidence for a causal relation between phenacetin-free analgesics and nephropathy.
Moehner Sabine, Lewis Michael, Graf Helmut, Heinemann Lothar AJ, van der Woude Fokke J, Assmann Anita, Kühl-Habich Doerthe   +6 more
doaj   +1 more source

Unveiling the self-association and desolvation in crystal nucleation

IUCrJ, 2021
As the first step in the crystallization process, nucleation has been studied by many researchers. In this work, phenacetin (PHEN) was selected as a model compound to investigate the relationship between the solvent and nucleation kinetics.
Danning Li, Yongli Wang, Shuyi Zong, Na Wang, Xin Li, Yuyuan Dong, Ting Wang, Xin Huang, Hongxun Hao   +8 more
doaj   +1 more source

Antipyrine kinetics in liver disease and liver transplantation [PDF]

, 1986
Antipyrine kinetics were studied in seven normal subjects, 10 patients with liver disease, and 13 clinically stable patients who received a liver transplant. Five patients were studied both before and after liver transplantation.
Burckart, Gilbert J, Gray, Jeffrey A, Mehta, Mehul U, Ptachcinski, Richard J, Starzl, Thomas E, Thiel, David H Van, Venkataramanan, Raman, Yang, Shuin L   +7 more
core   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Steven Good, Arantxa Horga, Nancy Agrawal, Janet Hammond   +10 more
wiley   +1 more source

Evaluation of an in-capillary approach for performing quantitative cytochrome P450 activity studies [PDF]

, 2018
An automated in-capillary assay requiring very small quantities of reagents was developed for performing in vitro cytochrome P450 (CYP450) drug metabolism studies. The approach is based on the following: (i) hydrodynamic introduction of nanoliter volumes
Curcio, R., Nicoli, R., Rudaz, S., Veuthey, J.-L   +3 more
core  

Schistosomiasis and Urinary Bladder Cancer in North Western Tanzania: A Retrospective Review of 185 Patients. [PDF]

, 2013
Worldwide, cancers of the urinary bladder are well known to be associated with environmental chemical carcinogens such as smoking and occupational exposure to polycyclic aromatic hydrocarbons.
A Yosry, AH Zarzour, AJ Fulford, AS Felix, B Diao, CC Guo, CF Heyns, DMPP Parkin, DMWS Parkin, E Jacobo, H Abol-Enein, H Dietrich, HK Salem, I Gouda, IA Mungadi, JNLP Kitinya, JO Thomas, Kahima Jackson, KM Badr, M El-Sebaie, MJ Hess, MM Koraitim, MN El-Bolkainy, MS Zaghloul, NG El-Mawla, Peter Fabian Rambau, Philipo L Chalya, R Gonzalez Resina, RM Cooppan, RS Barsoum, SA Fedewa, SA Sheweita   +31 more
core   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Printed bakery bags or coloured napkins: No health impairments are expected from the release of certain colourant components

Food Risk Assess Europe, Volume 4, Issue 2, April 2026.
Abstract Materials that come into contact with food as intended or as can be expected are also known as food contact materials or food contact articles. In addition to cardboard packaging, bakery bags and napkins, food contact materials made of paper and cardboard also include other utensils such as muffin tins and drinking straws.
German Federal Institute for Risk Assessment (BfR)
wiley   +1 more source

Microchip electrophoresis-electrochemical detection platform for analysis of drugs and their metabolites [PDF]

, 2015
U razdoblju ubrzanog rasta farmaceutske industrije razvoj postojećih analitičkih metoda je prespor i ne može zadovoljiti potrebe zahtjevnih metaboličkih analiza novih lijekova i novih kemijskih entiteta (kemikalija iz okoliša i kućanstva).
Lenić, Ines
core   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

Frontiers in Pharmacology, 2022
Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in ...
Yawen Yuan, Yawen Yuan, Qingfeng He, Shunguo Zhang, Min Li, Zhijia Tang, Xiao Zhu, Zheng Jiao, Weimin Cai, Xiaoqiang Xiang   +9 more
doaj   +1 more source