Results 61 to 70 of about 6,115 (211)

Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats

International Journal of Hepatology, 2018
Background and Aims. Both paracetamol (PA) and phenacetin (PH) are analgesic and antipyretic agents. Part of phenacetin therapeutic activity is attributed to its metabolism into paracetamol. Paracetamol causes direct hepatic oxidative stress damage.
Tahia H. Saleem, Nagwa Abo El-Maali, Mohammed H. Hassan, Nahed A. Mohamed, Nashwa A. M. Mostafa, Emaad Abdel-Kahaar, Azza S. Tammam   +6 more
doaj   +1 more source

Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids

ChemistryOpen, Volume 14, Issue 12, December 2025.
Two novel carboxamide hydrazone hybrids are synthesized and characterized. Structural, spectroscopic, and computational analyses reveal dominant hydrogen bonding, π–π stacking, and reactive sites. Compound 2b exhibits potent antibacterial activity against Staphylococcus aureus, highlighting its potential as a cost‐effective therapeutic agent.
Nabila A. Kheder, Mostafa E. Salem, Saied M. Soliman, Ismail A. Elhaty, Naglaa S. Mahmoud, Mohamed Abdel‐Megid, Kamal M. Dawood   +6 more
wiley   +1 more source

Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.

, 2006
Chronic use of phenacetin-containing analgesics has been associated with the development of renal cancer. To establish genotoxicity as a possible cause for the carcinogenic effect of phenacetin, we exposed wild type and DNA repair deficient Xpa-/- and ...
van Alphen, Niels, Westerman, Anja, Benthem, Jan van, Heisterkamp, Siem H, van Benthem, Jan, van Steeg, Harry, Kreijl, Coen F van, Steeg, Harrym van, Luijten, Mirjam, Speksnijder, Ewoud N, Alphen, Niels van, van Kreijl, Coen F, Beems, Rudolf B   +12 more
core   +1 more source

Metabolism of six CYP probe substrates in fetal hepatocytes

ADMET and DMPK, 2016
Cytochrome P-450 (CYP) are the most common drug metabolizing enzymes and are abundantly expressed in liver apart from kidney, lungs, intestine, brain etc. Their expression levels change with physiological conditions and disease states.
Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem A Khan   +2 more
doaj   +1 more source

Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse Headache: A Cross‐sectional Study

Brain and Behavior, Volume 15, Issue 11, November 2025.
Systemic inflammation indices (SII, SIRI, and AISI) were linked to clinical phenotypes in medication overuse headache (MOH). Specifically, higher SII and AISI showed independent associations with MOH. ABSTRACT Background The role of peripheral inflammation in medication overuse headache (MOH) remains inadequately understood.
Changling Li, Peiqi He, Mengmeng Ma, Yanbo Li, Jinghuan Fang, Qian Liu, Yang Zhang, Xin Jiang, Shiqin Li, Hui Lang, Ning Chen, Li He   +11 more
wiley   +1 more source

EVALUATION OF COCAINE SAMPLES SEIZED IN THE STREETS OF THE STATE OF RIO DE JANEIRO, BRAZIL

Química Nova
Fifty-two samples of street cocaine seized in the state of Rio de Janeiro, from May 2016 to April 2017, were evaluated according to their purity, presence of inorganic and sugar diluents and concentration of pharmacologically active adulterants.
Luiza D. Sant'Ana, Valeria C. de Sousa, Frances R. dos Santos, Bruno D. Sabino, Amadeu Cardoso, Marco Edilson F. de Lima, Rosane N. Castro   +6 more
doaj   +1 more source

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source

The Effect of Acetylsalicylic Acid, Caffeine, and Codeine on the Excretion of Phenacetin Metabolites

, 1972
The urinary excretion of total N-acetyl-p-aminophenol and conjugates (NAPA) and total 2-hydroxyphenetidin and conjugates (2-OHP) was studied after ingestion of 2 g phenacetin alone and also in combination with acetylsalicylic acid, caffeine, and codeine
Nasrollah T. Shahidi, Alec Gabe, M. Henry Gault   +2 more
core   +1 more source

Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache

Brain and Behavior, Volume 15, Issue 10, October 2025.
Patients with medication overuse headache (MOH) showed distinct inflammatory and oxidative stress profiles compared to healthy controls. Elevated values of lymphocyte to high‐density lipoprotein (HDL) ratio (LHR), monocyte to HDL ratio (MHR), and neutrophil to HDL ratio (NHR) were independently associated with MOH. ABSTRACT Background Recent scientific
Changling Li, Peiqi He, Yanbo Li, Mengmeng Ma, Ning Chen, Qian Liu, Yang Zhang, Xin Jiang, Shiqin Li, Hui Lang, Jinghuan Fang, Li He   +11 more
wiley   +1 more source

Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline and cerebral metabolic impairment. Yet, the therapeutic options for addressing the disease pathogenesis are limited. Here, we report an approach by targeting brain nucleoside homeostasis and energy metabolism to alleviate AD ...
Kuo‐Chen Wu, Chien‐Yu Lin, Thanh Tran, Jung‐Hsing Lin, Hsin‐Hsien Yeh, Chin‐Jui Ho, Yijuang Chern, Chun‐Jung Lin   +7 more
wiley   +1 more source