Results 41 to 50 of about 6,115 (211)
Caffeine-phenacetin interaction in the rat: effects on absorption, metabolism and locomotor activity
, 1977 The interactive effects of caffeine and phenacetin on the locomotor activity of the DA rat involved changes in absorption and metabolism as well as effects possibly exerted at the cns level.
G A Starmer +2 more
core +1 more source
Addiction, EarlyView.Abstract Aim To monitor community‐level consumption of 20 illicit drugs across urban areas of England using wastewater‐based epidemiology (WBE) surveillance at high temporal resolution. Design, setting, cases This study was conducted over a 12‐month period in 2022 sampling 24‐hour composite wastewater samples at 15 wastewater treatment plants (WWTPs ...
Helena Rapp‐Wright +14 more
wiley +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.ABSTRACT Background Drug interactions involving immunosuppressants can compromise transplant outcomes. Although repeated ketamine administration induces hepatic enzymes in experimental models, clinical reports of induced clearance of cytochrome P450 (CYP) substrates are lacking. Continuous subcutaneous ketamine infusions are increasingly used for acute
Jana Stojanova +9 more
wiley +1 more source
Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo.
Yiping Lin +8 more
doaj +1 more source
Contestation over a Profession's Memory: The UK Pharmacy Profession, 1880–1905
Journal of Management Studies, Volume 63, Issue 4, Page 1874-1906, June 2026.Abstract We draw on the historical case of the UK pharmacy industry from 1880–1905 to examine how, in the face of a competitive threat to their survival, lower status professionals seek to reinvigorate the memory of their role in providing community service in the public interest.
Graeme Currie, Andrew Wild, Andy Lockett
wiley +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Analgesics use and ESRD in younger age: a case-control study
BMC Nephrology, 2007 Background An ad hoc peer-review committee was jointly appointed by Drug Authorities and Industry in Germany, Austria and Switzerland in 1999/2000 to review the evidence for a causal relation between phenacetin-free analgesics and nephropathy.
Moehner Sabine +6 more
doaj +1 more source
Unveiling the self-association and desolvation in crystal nucleation
IUCrJ, 2021 As the first step in the crystallization process, nucleation has been studied by many researchers. In this work, phenacetin (PHEN) was selected as a model compound to investigate the relationship between the solvent and nucleation kinetics.
Danning Li +8 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou +10 more
wiley +1 more source