Results 71 to 80 of about 11,244 (259)

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source

EVALUATION OF COCAINE SAMPLES SEIZED IN THE STREETS OF THE STATE OF RIO DE JANEIRO, BRAZIL

Química Nova
Fifty-two samples of street cocaine seized in the state of Rio de Janeiro, from May 2016 to April 2017, were evaluated according to their purity, presence of inorganic and sugar diluents and concentration of pharmacologically active adulterants.
Luiza D. Sant'Ana, Valeria C. de Sousa, Frances R. dos Santos, Bruno D. Sabino, Amadeu Cardoso, Marco Edilson F. de Lima, Rosane N. Castro   +6 more
doaj   +1 more source

Incidence and treatment of cancer of the lip in Malta [PDF]

, 1970
Cancer of the lip is a condition which can be diagnosed at an early stage. If treated efficiently it carries an excellent prognosis. A brief account of its incidence in Malta and of the mode of treatment currently being adopted is presented.
Sultana, H.M.
core  

Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache

Brain and Behavior, Volume 15, Issue 10, October 2025.
Patients with medication overuse headache (MOH) showed distinct inflammatory and oxidative stress profiles compared to healthy controls. Elevated values of lymphocyte to high‐density lipoprotein (HDL) ratio (LHR), monocyte to HDL ratio (MHR), and neutrophil to HDL ratio (NHR) were independently associated with MOH. ABSTRACT Background Recent scientific
Changling Li, Peiqi He, Yanbo Li, Mengmeng Ma, Ning Chen, Qian Liu, Yang Zhang, Xin Jiang, Shiqin Li, Hui Lang, Jinghuan Fang, Li He   +11 more
wiley   +1 more source

Non-phenacetin analgesics and analgesic nephropathy: Clinical assessment of high users from a case-control study [1]* [PDF]

, 2017
Background. A recent large-scale case-control study on analgesic nephropathy (SAN) [1] found no increased risk of end-stage renal disease (ESRD) in users of combined or single formulations of phenacetin-free analgesics.
Graf, Helmut, Heinemann, Lothar, Koch, Karl-Martin, Michielsen, Paul, Mihatsch, Michael, Schnülle, Peter   +5 more
core  

Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature [PDF]

, 2016
BACKGROUND: Information about drug-drug interactions (DDIs) supported by scientific evidence is crucial for establishing computational knowledge bases for applications like pharmacovigilance.
Li, Lang, Soysal, Ergin, Wang, Jingqi, Wu, Heng-Yi, Xu, Hua, Xu, Jun, Zhang, Yaoyun   +6 more
core   +1 more source

Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline and cerebral metabolic impairment. Yet, the therapeutic options for addressing the disease pathogenesis are limited. Here, we report an approach by targeting brain nucleoside homeostasis and energy metabolism to alleviate AD ...
Kuo‐Chen Wu, Chien‐Yu Lin, Thanh Tran, Jung‐Hsing Lin, Hsin‐Hsien Yeh, Chin‐Jui Ho, Yijuang Chern, Chun‐Jung Lin   +7 more
wiley   +1 more source

The Impact of Vatinoxan on the Concentrations of Medetomidine, Midazolam, and Fentanyl in Central Nervous System After Subcutaneous Co‐Administration in Rats

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 5, Page 433-438, September 2025.
ABSTRACT Our aim was to investigate whether vatinoxan, a peripherally acting alpha2‐adrenoceptor antagonist, would affect the concentrations of medetomidine, midazolam, and fentanyl in the central nervous system after subcutaneous co‐administration. Twelve healthy male Wistar rats, aged between 13 and 15 weeks, were used in this study.
Juhana Honkavaara, Emily Lindh, Anna Meller, Karoliina Alm, Marja R. Raekallio, Pernilla Syrjä   +5 more
wiley   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science, Volume 12, Issue 32, August 28, 2025.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
wiley   +1 more source

Paracetamol and analgesic nephropathy: Are you kidneying me?

International Medical Case Reports Journal, 2014
Freya Waddington, Mark Naunton, Jackson Thomas Faculty of Health, University of Canberra, Canberra, ACT, Australia Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years,
Waddington F, Naunton M, Thomas J
doaj