Results 91 to 100 of about 6,115 (211)

In vivo effect of diallyl sulfide and cimetidine on phenacetin metabolism and bioavailability in rat.

, 2002
Numerous cytochrome P450 inhibitors have been described as effective modulators of cytochrome P450 isoforms activity in vitro. Their inhibitory efficiency may be considerably modified after in vivo application.
Zalewska, Katarzyna, Szutowski, Mirosław, Jadczak, Marta, Marek, Monika   +3 more
core  

A calorimetric study of the formation of phenacetin solid dispersions with PEG-1400 and pluronic F127 [PDF]

, 2013
The formation of solid dispersions is one of the methods of drug hydrophilization. The method of low-temperature differential scanning calorimetry showed the possibility to obtain phenacetin solid dispersions with polyethylene glycol and Pluronic F127 ...
Gerasimov A., Gorbatchuk V., Ziganshin M.   +2 more
core  

Omeprazole Does Not Enhance the Metabolism of Phenacetin, a Marker of CYP1A2 Activity, in Healthy Volunteers

, 1994
Omeprazole has been reported to increase cytochrome P450IA2 (CYP1A2) activity in vitro, but whether this effect also occurs in vivo is controversial. To clarify this issue, the effect of omeprazole (20 mg/day for 8 days) on the kinetics and metabolism of
S. Xiaodong, PERUCCA, EMILIO, GATTI, GIULIANA, CREMA, FRANCESCA, CIPOLLA, GIOVANNA, A. Bartoli   +5 more
core   +1 more source

An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes

Journal of Pharmaceutical Analysis, 2014
An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 (CYP) enzymes. This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaquine,
Jing-Jing Wang, Jian-Jun Guo, Jenny Zhan, Hai-Zhi Bu, Jiunn H. Lin   +4 more
doaj   +1 more source

Effect of malaria infection and endotoxin-induced fever on phenacetin o-deethylation by rat liver microsomes

, 1993
We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia colt endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar ...
Glazier, Anthony P., Ward, Steve, Edwards, Geoffrey, Kokwaro, Gilbert O., Breckenridge, Alasdair M.   +4 more
core   +1 more source

Differential inhibition of human liver phenacetin o-deethylation by histamine and four histamine h2-receptor antagonists

, 1988
1. The effects of histamine and four histamine H-2 receptor antagonists on phenacetin O-deethylation by microsomal preparations of four human livers were quantified by a radiometric-thin layer chromatographic method. 2. Histamine and three of these drugs,
Reilly, P. E B, Gillam, E. M J, Mason, S. R.   +2 more
core   +1 more source

Demonstrating the Influence of Solvent Choice and Crystallization Conditions on Phenacetin Crystal Habit and Particle Size Distribution

, 2015
Phenacetin was used as a model pharmaceutical compound to investigate the impact of solvent choice and crystallization conditions on the crystal habit and size distribution of the final crystallized product.
Croker, D. M., Lawrence, S. E., Horgan, D. E., Moynihan, H. A., Kelly, D. M., Rasmuson, Åke Christoffer,, Hodnett, B. K.   +6 more
core   +2 more sources

The Validation of Chromatographic Methods in the Detection of Cocaine and Diluents in Drugs Seized by the Civil Police in the State of Espírito Santo

Orbital: The Electronic Journal of Chemistry
Over the years, police have seized tons of cocaine in the form of cocaine hydrochloride and crack, which are often adulterated by traffickers. This work aims to use GC/MS and HPLC to determine the limit of detection (LoD) and limit of quantification ...
Karoline P. Miossi, Thays C. Valin, Ramon R. T. Bottocim, Bruno Q. Araújo, Wanderson Romão , Eustaquio V. R. de Castro, Valdemar Lacerda Jr., Alvaro Cunha Neto   +7 more
doaj   +1 more source

Plots of percentage of control in pharmacokinetic parameters of phenacetin versus C_max of baicalin.

, 2014
Plots of percentage of control in pharmacokinetic parameters of phenacetin versus Cmax of baicalin.
Hai-ling Qiao (5658073), Na Gao (137976), Fang-jun Liu (527726), Jun Zhou (6477), Lin-jing Jia (5658070), Bing Qi (492962), Yan Fang (443710)   +6 more
core   +1 more source

Phenacetin Abused [PDF]

BMJ, 1964
openaire   +5 more sources