Results 291 to 300 of about 283,091 (360)

Novel Insights Into the Bioactive Profile and Therapeutic Potentials of Indonesian Annona muricata Leaves

Chemistry &Biodiversity, EarlyView.
Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir, Fatimazahra Agouram, Hamid Kabdy, Mehdi Ait Laaradia, Khadija Oubella, Baslam Abdelmoniim, Aboufatima Rachida, Stefania Garzoli, Abderrahman Chait   +8 more
wiley   +1 more source

Efficacy of Non-opioid Analgesics in the Management of Postoperative Pain After Major Abdominal Surgery: A Comprehensive Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Cureus
Ponappan B, Elkandow A, Abdelrahim MG, Rehman MU, Shaban E, Shaban A, Shaban A, Abosamak MF, Zaki HA.   +8 more
europepmc   +1 more source

Eperua oleifera Ducke (Fabaceae) Oilresin Chemical Composition and the Isolation of a Natural Diterpenic Acid Methyl Ester

Chemistry &Biodiversity, EarlyView.
Eperua oleifera (Fabaceae) oilresin presents not only diterpenic acids, but also diterpenic acid methyl ester. ABSTRACT Eperua oleifera Ducke, commonly known as “copaíba‐jacaré,” produces oilresins traditionally used in folk medicine for wound healing and as antifungal and antibacterial agents, similar to those of Copaifera species.
Rayssa Ribeiro, Henrique M. G. Pereira, Alvicler Magalhães, Fernando Hallwass, Monica C. Padilha, Valdir F. Veiga‐Junior   +5 more
wiley   +1 more source

Ergotamine, triptans, and the global challenge of medication-overuse headache: a call to action from Asia-Oceania. [PDF]

J Headache Pain
Wijeratne T, Martelletti P.
europepmc   +1 more source

Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry.
Angela Palma Amorin, Sandra Layse Ferreira Sarrazin, Leomara Andrade da Silva, Thaiana Neves Coelho, Adriele Pantoja Cunha, Vitória Albuquerque de Lima, Domingas Machado da Silva, Pablo Luis Baia Figueiredo, Ricardo Bezerra de Oliveira   +8 more
wiley   +1 more source

Esketamine versus sufentanil as analgesics for sedation during painless gastrointestinal endoscopy: a double-blinded randomized controlled trial. [PDF]

Trials
Li TT, He XL, Tang HL, Li QJ, Lian SR, Wang X.   +5 more
europepmc   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Unveiling the Potential of a New β‐Cyclodextrin‐Suxibuzone Conjugate in Proteasome Regulation

ChemMedChem, EarlyView.
A novel β‐cyclodextrin‐suxibuzone conjugate enhances chymotryptic‐like activity of the 20S proteasome in a dose‐dependent manner. It remains stable and is internalized in SH‐SY5Y cells for 24 h. These findings suggest therapeutic potential for proteasome‐related disorders through targeted proteasome activation.
Noemi Bognanni, Stefania Zimbone, Maria Laura Giuffrida, Giuseppe Di Natale, Danilo Milardi, Graziella Vecchio, Valeria Lanza   +6 more
wiley   +1 more source

Biotinidase as a novel biomarker for pain assessment in dairy cattle. [PDF]

Pain Rep
Cohen-Zinder M, Shabtay A, Shor-Shimoni E, Honig HH, Asher A, Friedman S, Ross M, Yitzhak N, Shilo-Benjamini Y, Salzer Y.   +9 more
europepmc   +1 more source

Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics

ChemMedChem, EarlyView.
Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch, Hernan A. Bazán, Nicolas G. Bazan, Bhattacharjee Surjyadipta, Julio Alvarez‐Builla, Beatriz de Pascual‐Teresa   +5 more
wiley   +1 more source