Results 51 to 60 of about 2,982,740 (293)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Analog Reconfirable Circuits [PDF]

, 2014
The aim of this paper is to present an overview of a new branch of analog electronics represented by analog reconfigurable circuits. The reconfiguration of analog circuits has been known and used since the beginnings of electronics, but the universal ...
Malcher, A., Falkowski, P.
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Operating-point driven formulation for analog computer-aided design [PDF]

, 2013
In designing analog integrated circuits, the step of selecting device sizes and biases is crucial to enhance the final performance, power, and yield of the circuits.
ESTEBAN TLELO CUAUTLE
core  

All‐Optic Logical Operations Based on the Visible‐Near Infrared Bipolar Optical Response

Advanced Science
The burgeoning need for extensive data processing has sparked enthusiasm for the development of a novel optical logic gate platform. In this study, junction field‐effect phototransistors based on molybdenum disulfide/Germanium (MoS2/Ge) heterojunctions ...
Jie You, Zhao Han, Ningning Zhang, Qiancui Zhang, Yichi Zhang, Yang Liu, Yang Li, Jinping Ao, Zuimin Jiang, Zhenyang Zhong, Hui Guo, Huiyong Hu, Liming Wang, Zhangming Zhu   +13 more
doaj   +1 more source

Time-domain approach for analog circuits in deep sub-micron LSI

IEICE Electronics Express, 2018
As the scaling of LSI is going to extremely fine regions toward the ultimate feature size, one of difficulties faced in analog circuit design is reduction of the dynamic range (DR) due to the supply voltage reduction.
K. Asada, T. Nakura, T. Iizuka, M. Ikeda
semanticscholar   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Digital-analog quantum simulations with superconducting circuits [PDF]

, 2017
Quantum simulations consist in the intentional reproduction of physical or unphysical models into another more controllable quantum system. Beyond establishing communication vessels between unconnected fields, they promise to solve complex problems which
L. Lamata, Adrian Parra-Rodriguez, M. Sanz, E. Solano   +3 more
semanticscholar   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Exploiting device mismatch in neuromorphic VLSI systems to implement axonal delays [PDF]

, 2012
Axonal delays are used in neural computation to implement faithful models of biological neural systems, and in spiking neural networks models to solve computationally demanding tasks. While there is an increasing number of software simulations of spiking
Sadique Sheik, Sheik, S., Sheik, Sadique, Indiveri, G., Giacomo Indiveri, Elisabetta Chicca, Chicca, Elisabetta, Indiveri, Giacomo, Chicca, Elisabetta ; https://orcid.org/   +8 more
core   +1 more source