Results 51 to 60 of about 664,662 (293)

Low Turn-Off Loss 4H-SiC Insulated Gate Bipolar Transistor With a Trench Heterojunction Collector

IEEE Journal of the Electron Devices Society, 2020
In this work, an improved 4H-SiC insulated gate bipolar transistor (IGBT), or CTH-IGBT, with a trench p-polySi/p-SiC heterojunction on the backside of the device is proposed to reduce the turn-off energy loss (Eoff) and turn-off time (Toff).
Ying Wang, Cheng-Hao Yu, Hong-Kai Mao, Xue Wu, Fang-Wen Su, Xing-Ji Li, Jian-Qun Yang   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Low-voltage CMOS analog circuits

, 2022
S.864-872This contribution addresses the issue of low-voltage analog circuit design in CMOS technology. In particular, three areas of design will be discussed: switched-capacitor circuits, continuous-time circuits for low-frequency applications, and RF ...
Hammerschmidt, D., Brockherde, W., Hosticka, B.J., Kokozinski, R.   +3 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Fully-Depleted SOI CMOS Technology for Low-Voltage Low-Power Mixed Digital/Analog/Microwave Circuits

, 2019
This paper demonstrates that fully-depleted (FD) silicon-on-insulator (SOI) technology offers unique opportunities in the field of low-voltage, low-power CMOS circuits. Beside the well-known reduction of parasitic capacitances due to dielectric isolation,
Flandre, Denis, Silveira, Fernando, Eggermont, J. P, Viviani, A, Gillon, R, Jespers, Paul, De Ceuster, D, Ferreira, L, Chen, J, Valiente, Gabriel, Colinge, J. P, Gentinne, B, Vander Vorst, A, Raskin, J. P   +13 more
core   +5 more sources

The Case for Analog Circuit Verification

Electronic Notes in Theoretical Computer Science, 2006
The traditional approach to validate analog circuits is to utilize extensive SPICE-level simulations. The main challenge of this approach is knowing when all important corner cases have been simulated. A new alternative is to utilize formal verification techniques.
Chris J. Myers, Reid R. Harrison, David Walter, Nicholas Seegmiller, Scott Little   +4 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Applying a Robust Heteroscedastic Probabilistic Neural Network to Analog Fault Detection and Classification

, 2000
The problem of distinguishing and classifying the responses of analog integrated circuits containing catastrophic faults has aroused recent interest. The problem is made more difficult when parametric variations are taken into account. Hence, statistical
Chalk, C D, Zwolinski, M, Zwolinski, Mark, Yang, Zheng Rong, Williams, Alan Christopher, Yang, Z R, Williams, A C, Chalk, Chris D.   +7 more
core   +1 more source

Stochastic resonance in electrical circuits—I: Conventional stochastic resonance. [PDF]

, 1999
Stochastic resonance (SR), a phenomenon in which a periodic signal in a nonlinear system can be amplified by added noise, is introduced and discussed. Techniques for investigating SR using electronic circuits are described in practical terms.
Luchinsky, D. G., MANNELLA, RICCARDO, McClintock PVE, Stocks NG, Mannella, R., McClintock, Peter V. E., Luchinsky DG, Stocks, N. G.   +7 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source