Results 81 to 90 of about 886,439 (248)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Entropy and analog computation
, 1995 As computers become faster, smaller, and more efficient, it is natural that we ask ourselves what physical limits, if any, restrict our search for better computing machinery.
Kuwamoto, Sho
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Unconventional Computation Including Quantum Computation [PDF]
, 2022 Unconventional computation (or non-standard computation) refers to the use of non-traditional technologies and computing paradigms. As we approach the limits of Moore’s Law, progress in computation will depend on going beyond binary electronics and on ...
MacLennan, Bruce J
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Photonic Compute-in-Wire: Remotely Driven Photonic Deep Neural Network with a Single Nonlinear Loop
Advanced Devices & InstrumentationThe development of deep learning has motivated the advancement of unconventional computing that leverages analog physical systems such as analog electronics, spintronics, and photonics.
Mitsumasa Nakajima +4 more
doaj +1 more source
Accelerated Physical Emulation of Bayesian Inference in Spiking Neural Networks
Frontiers in Neuroscience, 2019 The massively parallel nature of biological information processing plays an important role due to its superiority in comparison to human-engineered computing devices. In particular, it may hold the key to overcoming the von Neumann bottleneck that limits
Akos F. Kungl +23 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Solving linear programming in one step with RRAM-based analog matrix computing
Frontiers in NanotechnologyLinear programming (LP) is among the most fundamental optimization techniques. However, solving LP problems on conventional digital hardware is increasingly constrained by the polynomial computational complexity of matrix operations.
Yubiao Luo +4 more
doaj +1 more source