Results 91 to 100 of about 298,951 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparative analysis of the random search procedures time complexity in the synthesis task under given acceptable values of its element parameters output characteristics and tolerances [PDF]

, 2015
Розглянуто приклад задачі аналізу аналогового фільтра при заданих допустимих значеннях вихідних характеристик та допусків на параметри його елементів. Розв’язком задачі синтезу аналогового фільтра є розв’язок інтервальної системи лінійних алгебраїчних ...
Krepych, S.
core  

Design and Development of an Electronic Interface for Acquiring Signals from a Piezoelectric Sensor for Ultrasound Imaging Applications

Technologies
The increasing demand for accurate and accessible medical imaging has driven efforts to develop technologies that overcome limitations associated with conventional imaging techniques, such as MRI and CT scans.
Elizabeth Espitia-Romero, Adriana Guzmán-López, Micael Gerardo Bravo-Sánchez, Juan José Martínez-Nolasco, José Alfredo Padilla Medina, Francisco Villaseñor-Ortega   +5 more
doaj   +1 more source

Automated integrated analog filter design issues / Automatizuotojo integrinių analoginių filtrų projektavimo ypatumai

Mokslas: Lietuvos Ateitis, 2015
An analysis of modern automated integrated analog circuits design methods and their use in integrated filter design is done. Current modern analog circuits automated tools are based on optimization algorithms and/or new circuit generation methods.
Karolis Kiela, Romualdas Navickas
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Detection of signals by the digital integrate-and-dump filter with offset sampling [PDF]

The Integrate and Dump Filter (IDF) is used as a matched filter for the detection of signals in additive white Gaussian noise. The performance of the digital integrate and dump filter is evaluated.
Hurd, W. J., Sadr, R.
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

A Hybrid Gain Analog Offline EnKF for Paleoclimate Data Assimilation

Journal of Advances in Modeling Earth Systems
For Paleoclimate data assimilation (PDA), a hybrid gain analog offline ensemble Kalman filter (HGAOEnKF) is proposed. It keeps the benefits of the analog offline ensemble Kalman filter (AOEnKF) that constructs analog ensembles from existing climate ...
Haohao Sun, Lili Lei, Zhengyu Liu, Liang Ning, Zhe‐Min Tan   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source