Results 41 to 50 of about 3,333,515 (295)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Generation and Verification of Tests for Analog Circuits Subject to Process Parameter Deviations

, 2004
The paper presents a test stimulus generation and fault simulation methodology for the detection of catastrophic faults in analog circuits. The test methodology chosen for evaluation is RMS AC supply current monitoring.
Chalk, CD, Zwolinski, M, Spinks, SJ, Bell, IM   +3 more
core   +1 more source

All‐Optic Logical Operations Based on the Visible‐Near Infrared Bipolar Optical Response

Advanced Science
The burgeoning need for extensive data processing has sparked enthusiasm for the development of a novel optical logic gate platform. In this study, junction field‐effect phototransistors based on molybdenum disulfide/Germanium (MoS2/Ge) heterojunctions ...
Jie You, Zhao Han, Ningning Zhang, Qiancui Zhang, Yichi Zhang, Yang Liu, Yang Li, Jinping Ao, Zuimin Jiang, Zhenyang Zhong, Hui Guo, Huiyong Hu, Liming Wang, Zhangming Zhu   +13 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Low Turn-Off Loss 4H-SiC Insulated Gate Bipolar Transistor With a Trench Heterojunction Collector

IEEE Journal of the Electron Devices Society, 2020
In this work, an improved 4H-SiC insulated gate bipolar transistor (IGBT), or CTH-IGBT, with a trench p-polySi/p-SiC heterojunction on the backside of the device is proposed to reduce the turn-off energy loss (Eoff) and turn-off time (Toff).
Ying Wang, Cheng-Hao Yu, Hong-Kai Mao, Xue Wu, Fang-Wen Su, Xing-Ji Li, Jian-Qun Yang   +6 more
doaj   +1 more source

Modeling and Simulation of Monolithic Single-Supply Power Operational Amplifiers

Energies, 2021
In this paper a simple PSpice (Personal Simulation Program with Integrated Circuit Emphasis) macro-model was developed, and verified for monolithic power operational amplifiers operated with a single-supply voltage.
Ivailo Milanov Pandiev
doaj   +1 more source

Applications of evolutionary algorithms in the design automation of analog integrated circuits [PDF]

, 2010
During the last decade, evolutionary algorithms (EAs) have shown its usefulness for solving multi-objective optimization problems. In the field of analog Integrated Circuits (ICs), they provide a set of feasible solutions for the optimal synthesis and ...
MIGUEL AURELIO DUARTE VILLASEÑOR, IVICK GUERRA GOMEZ, LUIS GERARDO DE LA FRAGA, ESTEBAN TLELO CUAUTLE, GERARDO REYES SALGADO, GUSTAVO RODRIGUEZ GOMEZ, CARLOS ALBERTO REYES GARCIA, GEORGINA FLORES BECERRA   +7 more
core  

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Visible–near‐infrared wavelength‐selective photodetection and imaging based on floating‐gate phototransistors

InfoMat
Wavelength selective imaging has a wide range of applications in image recognition and other application scenarios, which can effectively improve the recognition rate of objects.
Bo Wang, Ningning Zhang, Jie You, Xin Wu, Yichi Zhang, Tian Miao, Yang Liu, Zuimin Jiang, Zhenyang Zhong, Hao Sun, Hui Guo, Huiyong Hu, Liming Wang, Zhangming Zhu   +13 more
doaj   +1 more source