Results 171 to 180 of about 326,210 (336)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optical logic convolutional neural network. [PDF]

Sci Adv
Zhang W, Li J, Zhang S, Wu B, Wang Y, Zhou H, Dong J, Zhang X.   +7 more
europepmc   +1 more source

Differential Difference Current Conveyor Transconductance Amplifier: A New Analog Building Block for Signal Processing [PDF]

, 2011
Neeta Pandey, Sajal K. Paul
openalex   +1 more source

Performance parameters optimization of CMOS analog signal processing circuits based on smart algorithms

, 2022
Israa Mohammed Rasheed, Hassan Jassim Motlak   +1 more
openalex   +2 more sources

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source

Repurposing Si CMOS nonidealities for stochastic and analog image processing. [PDF]

Sci Adv
Kwak B, Koo RH, Han C, Shin Y, Choi J, Kim D, Lee J, Im J, Cho Y, Lee JH, Shin W, Kwon D.   +11 more
europepmc   +1 more source

Analog Signal Processing System Design Assisted by CAI Function and Knowledge Data Base

, 1993
Tsugio Matsuura, Keiji Taniguchi, Keiichi Senda   +2 more
openalex   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Neuromorphic photonic computing with an electro-optic analog memory. [PDF]

Nat Commun
Lam S, Khaled A, Bilodeau S, Marquez BA, Prucnal PR, Chrostowski L, Shastri BJ, Shekhar S.   +7 more
europepmc   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source