Results 61 to 70 of about 1,148,055 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analogy Mining for Specific Design Needs

, 2017
Finding analogical inspirations in distant domains is a powerful way of solving problems. However, as the number of inspirations that could be matched and the dimensions on which that matching could occur grow, it becomes challenging for designers to ...
Bahdanau Dzmitry, Bird Edward Loper, Blei David M., Fu Katherine, Gentner Dedre, Gentner Dedre, Gentner Dedre, Guroff Margaret, Library, Mikolov Tomas, Pennington Jeffrey, Venema Vibeke   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The psychic life of freedom: Social pathology and its symptoms [PDF]

Filozofija i Društvo, 2017
This paper discusses the relationship between Axel Honneth’s intersubjective theory of recognition and his political theory of democratic ethical life by addressing the potentials and difficulties attached to the notion of social pathology ...
Bueno Arthur
doaj   +1 more source

Complexity vs Energy: Theory of Computation and Theoretical Physics [PDF]

, 2013
This paper is a survey dedicated to the analogy between the notions of {\it complexity} in theoretical computer science and {\it energy} in physics. This analogy is not metaphorical: I describe three precise mathematical contexts, suggested recently, in ...
Manin, Yuri I.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

An analogical approach to the typology of inflectional complexity

Journal of Language Modelling
This paper studies the inflectional complexity of nouns, verbs and adjectives in 137 datasets, across 71 languages. I follow Ackerman and Malouf (2013) in distinguishing between E(numerative) complexity and I(ntegrative) complexity.
Matías Guzmán Naranjo
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Zagadnienie hipotez i teorii naukowych w rozważaniach filozoficznych Mariana Smoluchowskiego

Zagadnienia Filozoficzne w Nauce, 2017
The main purpose of this paper is to investigate and reconstruct the philosophical thoughts in Marian Smoluchowski’s papers (in his publications and in unknown manuscripts as well). He was an outstanding Polish physicist, who lived at the turn of the XIX
Małgorzata Dziekan
doaj  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source