Results 111 to 120 of about 124,182 (298)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Sources écrites et archéologiques du Pont Nord-Ouest. Analyse comparative
, 1990 Vinogradov Juri G., Domanskij Iaroslaw, Marcenko Konstantin K. Sources écrites et archéologiques du Pont Nord-Ouest. Analyse comparative. In: Le Pont-Euxin vu par les Grecs : sources écrites et archéologie. Symposium de Vani (Colchide), septembre-octobre
Marčenko, Konstantin Konstantinovič +2 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Analyse comparative du droit législatif en matière de prostitution
, 2006 Ce travail de maîtrise est une analyse comparative du droit législatif en matière de prostitution. Plus précisément, on tente de savoir si les systèmes législatifs en matière de prostitution ont une influence sur la dynamique prostitutionnelle mondiale ...
Tremblay, Yves Junior
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 1992 Cordini Giovanni. La notion d'ingérence en matière d'environnement. L'apport d'une analyse comparative des législations. In: Revue internationale de droit comparé. Vol. 44 N°3, Juillet-septembre 1992. pp.
Cordini, Giovanni
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2010 Une analyse comparative de l'importance de l'ingression incisive chez l'enfant et l'adulte indique que l'âge et le type facial ne sauraient influer sur les caractéristiques essentielles de cette ...
Ronald L. Otto
core +1 more source