Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Policy Implementation in the Digital Era: A Comprehensive Analysis of the Electronic-Based Government System (SPBE) in Indonesia. [PDF]
Yulianto T, Saleh C, Noor I, Suryadi S.
europepmc +1 more source
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Introduction to the special issue: Global South histories of madness - new perspectives on mental troubles and psychiatry from Latin America and Africa in the 19th and 20th centuries. [PDF]
Favier I, Tiquet R.
europepmc +1 more source
Planning and delivering co-creation workshops: practical lessons from digital health device design. [PDF]
McConnell-Trevillion A +5 more
europepmc +1 more source
Perceived benefits and constraints of artificial intelligence integration in teachers' college libraries: a TAM-based study. [PDF]
Chibidi I, Magwa L.
europepmc +1 more source
Best practices in methodological frameworks for evaluating procedure-based treatments in traditional, complementary and integrative medicine: a scoping review protocol. [PDF]
Liu Y +7 more
europepmc +1 more source
Editorial: Overcoming (in)visible barriers: gender, work and discrimination. [PDF]
Ehrstein Y, Maiani S, Andrade C.
europepmc +1 more source
Analysis of paddy grain hulling behaviour for rice grain quality improvement in centrifugal hulling using CFD-DEM method. [PDF]
Li H +7 more
europepmc +1 more source

