Results 101 to 110 of about 48,397,054 (331)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Health system analysis: Pakistan and Afghanistan

open access: yesInternational Journal of Endorsing Health Science Research, 2015
The purpose of this paper is to analyze the health system of the two neighboring countries i.e. Pakistan and Afghanistan; and recommend strategies to translate the available opportunities into effective actions within the countries.
Wais Mohammad Qarani, Samina Iqbal Kanji
doaj   +1 more source

DOMINO PROJECT GUIDELINES FOR EXPERIMENTAL PRACTICE [PDF]

open access: yes, 2018
The aim of this handbook of experimental guidelines is to level out analyses run during the "Domino project" on practices for sustainable management of organic apple orchard and vineyard in field ...
Dzhuvinov, Vasiliy   +8 more
core  

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

Fifa U-20 World Cup 2013: Analysis and evaluation of goals scored

open access: yesRevista Brasileira de Futsal e Futebol, 2016
This study was conducted to analyze the goals scored in 2013 FIFA U-20 World Cup and examine several variables from different aspects. In this research, technical parameters such as shots, shots on goal, corner kicks, goal areas, timetables of goals, the
Kemal Göral
doaj  

A Text-book of Quantitative Chemical Analysis [PDF]

open access: bronze, 1923
Alexander Charles Cumming   +1 more
openalex   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

open access: yes
FEBS Letters, EarlyView.
Igor Zivkovic   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Shakespeare's Philosophy of Music

open access: yesMusical Offerings, 2017
Shakespeare is one of the most widely read figures in literature, but his use of music is not usually touched on in literary discussions of his works. In this paper, I discuss how Shakespeare portrays music within the context of his plays, through both ...
Emily A. Sulka
doaj   +1 more source

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