Results 121 to 130 of about 27,676,138 (298)
COREnet: the fusion of social network analysis and target audience analysis [PDF]
The purpose of this capstone is to highlight and explain how the target audience analysis (TAA) process can be enhanced by incorporating aspects of influence theory, social movement theory (SMT) and social network analysis (SNA).
Orkins, William R., Kiernan, Carla A.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The table of contents for this item can be shared with the requester. The requester may then choose one chapter, up to 10% of the item, as per the Fair Dealing provision of the Canadian Copyright ActTobacco Production is labour intensive, leading to use ...
Kenya Tobacco Control Situational Analysis Consortium
core
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Objectives. Analysis of the various architectures of computing systems (CSs) used in recent decades has allowed us to identify the most common structures. One of the key features is the use of mass-produced equipment to create data processing subsystems (
G. V. Petushkov, A. S. Sigov
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Subject Analysis, Content Analysis and Domain Analysis
From the perspective of the constant increase in data and information, consider in Library and Information Science that the correct analysis and representation of the contents of documents analyzed in specific domains is essential for the retrieval, organization, and dissemination of information.
Alves Silva Portella, Tauany Lorena +1 more
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source

