Results 111 to 120 of about 48,044,330 (330)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Analysis of the Application of Universal Design Standards to Interior-Architecture Design [PDF]

open access: yes, 2019
A lot of research shows the findings of cases of public facilities that are not accessible to people with disabilities and see the importance of a design especially in the field of architecture-interior that is able to produce a user-friendly and barrier-
Cardiah, T. (Tita )   +4 more
core  

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Funding Analysis Of Murabahah, Musyarakah, And Mudharabah On Return On Asset On Sharia Banks In Indonesia [PDF]

open access: yes, 2019
The purpose of this study to examine, analyze, and prove the effect of mudharabah financing, musyarakah financing and murabahah financing on return on assets of Sharia Commercial Banks in Indonesia.
Ernayani, R. (Rihfenti)   +1 more
core  

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Estudio exergético del espacio climatizado en una embarcación fluvial;Exergy Study of air-conditioned space on a river vessel.

open access: yesRevista Científica de Ingeniería Energética, 2015
En este trabajo se presentan los resultados del análisis exergético realizado al sistema de acondicionamiento de aire de una embarcación fluvial. El estudio se realizó en un prototipo a escala de laboratorio, el cual simula uno de los locales de la ...
Juan Gabriel Fajardo Cuadro   +2 more
doaj  

Diffusion of gases dissolved in peat pore water [PDF]

open access: yesMires and Peat, 2012
Diffusion is usually thought to be ineffective at transporting solutes over distances of several metres – the depth of many peat deposits. But this is to neglect the importance of time. We derive equations that show that in peat that has accumulated over
R.S. Clymo, M.M.R. Williams
doaj  

Behaviour change techniques: the development and evaluation of a taxonomic method for reporting and describing behaviour change interventions (a suite of five studies involving consensus methods, randomised controlled trials and analysis of qualitative data)

open access: yesHealth Technology Assessment, 2015
Background: Meeting global health challenges requires effective behaviour change interventions (BCIs). This depends on advancing the science of behaviour change which, in turn, depends on accurate intervention reporting.
Susan Michie   +5 more
doaj   +1 more source

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