Results 221 to 230 of about 48,397,054 (331)

The analysis of snow from the neighbourhood of chemical works and various other places [PDF]

, 1892
J. Carter Bell
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

The Intracerebral Haemorrhage in Patients With Dengue Fever: A Systematic Review and Meta-Analysis. [PDF]

Rev Med Virol
Xu M, Dong M.
europepmc   +1 more source

VARICOSE VEINS. AN ANALYSIS OF THE RESULTS OF VARIOUS OPERATIVE PROCEDURES

, 1942
S. W. Moore, George M. Knapp
openalex   +2 more sources

THE FUNCTIONAL ANALYSIS OF THE CORTICAL CENTRES BY MEANS OF LOCAL CHEMICAL STIMULATION [PDF]

, 1916
Silvestro Baglioni
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Correcting for Genomic Inflation Leads to Loss of Power in Large-Scale Genome-Wide Association Study Meta-Analysis. [PDF]

Genet Epidemiol
Singh A, Southam L, Hatzikotoulas K, Rayner NW, Suzuki K, Taylor HJ, Yin X, Mandla R, Huerta-Chagoya A, Morris AP, Zeggini E, Bocher O.   +11 more
europepmc   +1 more source

METHODS IN THE QUANTITATIVE ANALYSIS OF PLANT GROWTH—A REPLY TO CRITICISM [PDF]

, 1921
George E. Briggs, C. West
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Family Resilience in the ICU: A Concept Analysis. [PDF]

Nurs Crit Care
Sun S, Song C, Guan L, Xiaoling T, Wu C.
europepmc   +1 more source