Results 81 to 90 of about 110,798 (311)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Tạp chí Khoa họcThe article begins by applying moral literary criticism in teaching literary text comprehension and provides an overview of the theory of ethical literary criticism.
Do Thi Thuy Duong
doaj +1 more source
Automated facial expression analysis of participants self-criticising via the two-chair technique: exploring facial behavioral markers of self-criticism [PDF]
, 2023 Júlia Halamová +3 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Public urban space: The linguistic turn
Cogent Arts & Humanities, 2018 Urban public open space is a myriad between the physical and the social. Their relationship has been conceived in various terms; the focus shifting between one and the other; nevertheless, in most cases, the language of criticism has so far been lacking,
Nabil Abu-Dayyeh
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Analysis of qRed Rose and White Roseq from the Perspective of Psychoanalytic Criticism [PDF]
, 2018 Min Yang
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
On the method of analyzing the “nature-text” in ethical literary criticism
НеофилологияINTRODUCTION. The application of the method of “text-nature” analysis is discussed, based on the concept of “umwelt”, which is of decisive importance for ethical literary criticism.
Yao Tingting, Ye Lin
doaj +1 more source