Results 41 to 50 of about 482,820 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Distortional influence of pallet rack uprights subject to combined compression and bending [PDF]

, 2016
A pallet rack is a structure in which the beams and uprights are cold-formed steel sections. The beam-upright connections are normally clipped in order to select the beam levels required and for ease of assembly.
Bonada Bo, Jordi, Casafont Ribera, Miguel, Pastor Artigues, María Magdalena, Roure Fernández, Francisco   +3 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Aerodynamic analysis of compliant journal foil bearings [PDF]

, 2013
This thesis provides a detailed study about the aerodynamic analysis of compliant journal foil bearings. In high speed turbomachinery elements, conventional bearings can’t be used since at such a high speed (50000-80000) rpm these bearings get worn and ...
Saha, Shubhendra Nath
core  

Degradation analysis of concrete bridge load-bearing capacity based on crack distribution

Journal of Highway and Transportation Research and Development (English Edition)
In-service reinforced concrete bridges, following prolonged operational periods, frequently undergo alterations in structural integrity and significant deterioration of material properties. As a result, it becomes imperative to evaluate and analyze these bridge structures.
Zhirong Ma, Xiaoguang Wu, Xingke Chang, Jiang Huang   +3 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Effect of a surface tension imbalance on a partly submerged cylinder [PDF]

, 2017
We perform a static analysis of a circular cylinder that forms a barrier between surfactant-laden and surfactant-free portions of a liquid$-$gas interface.
Chaurasia, Vikash, Fried, Eliot, Janssens, Stoffel D.   +2 more
core   +3 more sources

Influence of construction method on the load bearing capacity of skew masonry arches

Engineering structures, 2018
This paper investigates the influence of construction method (e.g. false skew, helicoidal and logarithmic method) on the mechanical behaviour and load carrying capacity of single span skew masonry arches.
T. Forgács, V. Sarhosis, K. Bagi
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Evaluation of the stiffness modulus of bituminous mixtures using laboratory tests (NAT) validate by field back-analysis [PDF]

, 2005
This paper concerns the evaluation of the stiffness modulus of bituminous mixtures by using the Nottingham Asphalt Tester (NAT). On the basis of indirect tensile laboratory test results, a practical model for stiffness modulus prediction in pavement ...
Correia, A. Gomes, Neves, J.
core