Results 61 to 70 of about 54,461 (266)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Simulation analysis of energy absorption characteristics of hyperbolic shallow shell anti-impact energy absorbing components

Meikuang Anquan
To enhance the impact resistance and energy absorption performance of hydraulic supports in mitigating coal mine rock burst, a hyperbolic shallow shell anti-impact energy-absorbing component was designed.
Dong AN, Jiawei TU, Hailiang XU, Zhiyang WANG, Runsong TANG   +4 more
doaj   +1 more source

The Effective Application and Research of Foundation Reinforcement in Civil Engineering Construction

Chemical Engineering Transactions, 2017
In this paper, the bearing capacity of the foundation is analyzed by means of numerical model tests. By changing the natural foundation of the coal gangue carrier size and position parameters obtained by the analysis are the main factors that influence ...
Yonghe Liu, Yu Liu
doaj   +1 more source

Analysis of the Ultimate Load-Bearing Capacity of Steel-Clad Concrete-Filled Steel Tube Arched Protective Doors under Blast Shock Waves

Buildings, 2023
The mechanism of blast damage to steel-clad concrete-filled steel tube (SCCFST) arched protective doors is studied using the dynamic response characteristics of such loads under the action of blast shock wave loads, and the ultimate blast load-bearing ...
Shangwei Dong, Zhimin Tian, Xingwei Cao, Ce Tian, Zhenyu Wang   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Investigation and numerical simulation study on the vertical bearing mechanism of large-diameter overlength piles in water-enriched soft soil areas

Applied Rheology
With the development of urbanization, there is an increasing demand for higher land utilization rates, leading to the emergence of high-rise residential and commercial complexes.
Liang Huayan, Wang Zhi, Zhao Biao, Xu Yan, Li Zheng, Ding Xuanming   +5 more
doaj   +1 more source

CatBoost algorithms to predict the load-bearing capacity of centrally compressed short CFST columns of circular cross-section [PDF]

E3S Web of Conferences
The article investigates the use of regression models, GradientBoostingRegressor and RandomForestRegressor, to predict the load-bearing capacity of centrally compressed short concrete filled steel tubular columns.
Kondratieva Tatiana, Chepurnenko Anton, Poliakova Karolina, Rodionov Kirill   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source