Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Numerical evidence for phase transitions of NP-complete problems for instances drawn from Lévy-stable distributions [PDF]
Random NP-Complete problems have come under study as an important tool used in the analysis of optimization algorithms and help in our understanding of how to properly address issues of computational intractability.
Connelly, Abram, Abram Connelly
core +1 more source
Fifty years of scheduling: a survey of milestones [PDF]
Scheduling has become a major field within operational research with several hundred publications appearing each year. This paper explores the historical development of the subject since the mid 1950s when the landmark publications started to appear.
Strusevich, Vitaly A. +5 more
core +1 more source
B-Tree Algorithm Complexity Analysis to Evaluate the Feasibility of its Application in the University Course Timetabling Problem [PDF]
Abstract This paper presents a comparative analysis of complexity between the B-TREE and the Binary Search Algorithms, both theoretically and experimentally, to evaluate their efficiency in finding overlap of classes for students and teachers in the University Course Timetabling Problem (UCTP).
Marco Antonio Cruz Chvez +1 more
openaire +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
On the probabilistic min spanning tree Problem [PDF]
International audienceWe study a probabilistic optimization model for min spanning tree, where any vertex v i of the input-graph G(V, E) has some presence probability p i in the final instance G′ ⊂ G that will effectively be optimized.
Paschos, V.T. +10 more
core +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Complexity analysis of primal-dual algorithms for the semidefinite linear complementarity problem
In this paper a primal-dual path-following interior-point algorithm for the monotone semidefinite linear complementarity problem is presented. The algorithm is based on Nesterov-Todd search directions and on a suitable proximity for tracing approximately the central-path.
Mohamed Achache, Naima Boudiaf
openaire +3 more sources
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Revisiting Online Algorithms: A Survey of Set Cover Solutions Beyond Competitive Analysis
Online algorithms are crucial for real-time decision-making and adaptability across diverse fields, such as operations research, computer science, and combinatorics. These algorithms handle data incrementally and make decisions without prior knowledge of
Christine Markarian +2 more
doaj +1 more source

