Results 151 to 160 of about 176,051,905 (236)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Skin thickness alterations in pressure injury tissue: insights from high-frequency ultrasound and mixed-design analysis of variance. [PDF]

Front Physiol
Tang L, Zhang J, Zhou W, Huang J, Diao D, Zhong L, Zhang J.   +6 more
europepmc   +1 more source

Data showing that post-traumatic stress symptoms and defense mechanisms change based on perceived stress levels: A multivariate analysis of variance approach during the COVID-19 pandemic. [PDF]

Data Brief, 2023
Topino E, Gori A.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Regional Expression of Vimentin, S100, and Epithelial Membrane Antigen in the Human Medial Collateral Ligament: A Robust Two-Way Analysis of Variance. [PDF]

J Funct Morphol Kinesiol
Stamenov N, Landzhov B, Piagkou M, Al-Sadek A, Gaydarski L, Petrova K, Luchev G, Ananiev J, Dimitrova IN, Georgiev GP.   +9 more
europepmc   +1 more source

Schizophrenia Increases Variability of the Central Antioxidant System: A Meta-Analysis of Variance From MRS Studies of Glutathione. [PDF]

Front Psychiatry, 2021
Palaniyappan L, Sabesan P, Li X, Luo Q.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Sample size determination for hypothesis testing on the intraclass correlation coefficient in a two-way analysis of variance model. [PDF]

Br J Math Stat Psychol
Mondal D, Cassese A, Candel MJJM, Vanbelle S.   +3 more
europepmc   +1 more source

D-MANOVA: fast distance-based multivariate analysis of variance for large-scale microbiome association studies. [PDF]

Bioinformatics, 2021
Chen J, Zhang X.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source