Results 71 to 80 of about 4,772,800 (256)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
American Journal of Orthodontics and Dentofacial Orthopedics, 2015 Kandethody M. Ramachandran +1 more
openaire +3 more sources
An alternative analysis of variance [PDF]
, 2008 The one-way analysis of variance is a staple of elementary statistics courses. The hypothesis test of homogeneity of the means encourages the use of the selected-model based estimators which are usually assessed without any regard for the uncertainty ...
Longford, Nicholas T.
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Functional analysis of variance for association studies. [PDF]
PLoS One, 2014 While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only account for a small proportion of heritability.
Vsevolozhskaya OA +4 more
europepmc +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Analysis of variance for bayesian inference [PDF]
This paper develops a multi-way analysis of variance for non-Gaussian multivariate distributions and provides a practical simulation algorithm to estimate the corresponding components of variance. It specifically addresses variance in Bayesian predictive
Amisano, Gianni, Geweke, John
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The use of analysis of variance and three-way factor analysis methods for studying the quality of a sensory panel [PDF]
, 2007 In sensory analysis a panel of assessors evaluate a collection of samples/products with respect to a number of sensory characteristics. Assessments are collected in a threeway data matrix crossing products, attributes and assessors.
Brockhoff, Per Bruun +2 more
core
Flexibility and Geometric Optimization of a New Structure for a Polymer Stent with the Finite Element Method [PDF]
مهندسی مکانیک شریفCardiovascular diseases cause many problems for patients, and the main reason is associated with arteriosclerosis. According to the American Heart Association, atherosclerosis is a condition caused by the accumulation of a substance called plaque in the ...
M. Khatami +3 more
doaj +1 more source