Results 111 to 120 of about 4,873,644 (382)
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao+7 more
wiley +1 more source
Descriptive currents in philosophy of religion for Hebrew Bible studies
This article argued that the utilisation of philosophy of religion in the study of the Hebrew Bible is possible if we look beyond the stereotype of erroneously equating the auxiliary field with natural theology, apologetics or atheological criticism ...
Jacobus W. Gericke
doaj +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi+5 more
wiley +1 more source
Several analytic studies of surfaces of nonparallel and nonintersecting lines (skewed). [V.] [PDF]
Vilém Jung
openalex +1 more source
Analytic curves are classified w.r.t. their symmetries under a regular Lie group action on an analytic manifold. We show that an analytic curve is either exponential or splits into countably many analytic immersive curves; each of them decomposing ...
Hanusch, Maximilian
core
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling+4 more
wiley +1 more source
Remarks on the analytic theory of stright lines [PDF]
František Josef Studnička
openalex +1 more source
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
Representing synthetic vs. analytic suffixation in Strict CV in English. Some problematic cases
The aim of this paper is to present some additions and corrections to a model I proposed in an earlier article (Kristó 2006) concerning the formal distinction between analytic and non-analytic (synthetic) suffixation, couched in a Strict CV framework.
László Kristó
doaj