Results 131 to 140 of about 744,681 (316)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Data-Analytic-Based Adaptive Solar Energy Forecasting Framework

, 2018
Data-Analytic-Based Adaptive Solar Energy Forecasting ...
MM Jamshidi (15863177), YS Manjili (15863174), R Vega (13336743)   +2 more
core  

Kant’tan Kripke’ye: Analitiklik, Zorunluluk, A Priori İlişkisi

Felsefe Dünyası
Bu çalışmada zorunluluğun, analitik ve a priori kavramlarıyla olan bağı çağdaş felsefedeki tartışmalarla ilgisi içerisinde incelenmeye çalışılacaktır. Bu doğrultuda ilk olarak Kant’ın yargı teorisinden hareketle yaptığı sınıflandırma ele alınacaktır.
Murat Fatih Yazıcı
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Analytic Theology and the Phenomenology of Faith

, 2016
This article argues that analytic philosophy has a “convincingness deficit”; that proponents of the analytic method’s application to questions of theology must consider whether it is the best tool for the purpose at hand; and that phenomenology – in ...
Kate Kirkpatrick, Kirkpatrick, Kate, Kirkpatrick, Katherine; id_orcid   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Coefficient Estimates for Analytic and Bi-Univalent Functions Classes Defined by Generalized Mathieu-Type Power Series

Mathematics
In this paper, we introduce two novel subclasses, MSκ*(δ,β,μ) and NSκ*(φ), of analytic and bi-univalent functions associated with generalized Mathieu-type power series in the open unit disk. By employing coefficient-based techniques, we derive new bounds
Feras Yousef, Tariq Al-Hawary, Khadeejah Rasheed Alhindi, Hamed Obiedat   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source