Results 81 to 90 of about 596,053 (286)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Parametric formal Gevrey asymptotic expansions in two complex time variable problems [PDF]

open access: yesOpuscula Mathematica
The analytic and formal solutions to a family of singularly perturbed partial differential equations in the complex domain involving two complex time variables are considered.
Guoting Chen   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Analytic continuation of group representations-V [PDF]

open access: yesCommunications in Mathematical Physics, 1966
Verf. diskutiert die explizite Konstruktion analytischer Fortsetzungen von Darstellungen kontinuierlicher Gruppen mit Hilfe der Gell-Mann Formel, die in den früheren Arbeiten dieser Serie eingeführt wurde (s. Teil V [ibid. 5, 157--190 (1967; Zbl 0145.44405)] und die dort zitierten Vorgänger).
openaire   +14 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

On estimations of solutions of one convolution type equation

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2013
We consider a convolution type equation in a semi-strip for the functions belonging to the Hardy-Smirnov space. Estimations of solutions are obtained in terms of analytic continuation.
B. V. Vynnytskyi, V. M. Dilnyi
doaj   +3 more sources

The θ-dependence of the Yang-Mills spectrum from analytic continuation

open access: yesJournal of High Energy Physics
We study the θ-dependence of the string tension and of the lightest glueball mass in four-dimensional SU(N) Yang-Mills theories. More precisely, we focus on the coefficients parametrizing the O θ 2 $$ \mathcal{O}\left({\theta}^2\right) $$ dependence of ...
Claudio Bonanno   +3 more
doaj   +1 more source

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