Results 151 to 160 of about 16,514,849 (251)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Cumulative Household Food Insecurity Is Associated with Adverse Eating Behaviors Among Youth Exposed to Gestational Diabetes in Utero. [PDF]

Nutrients
Haushalter K, Davis JN, Faith MS, Zhu Y, Hudson EA, King AS, Gunderson EP.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Physiotherapists are underutilised in health-sector responses to gender-based violence: A cross-sectional survey of preparedness across Spanish-speaking countries. [PDF]

PLOS Glob Public Health
de León Pérez ME, Magos Chong MJ, Gamboa Gutiérrez MA, Figueroa Valero J, García Tarrazo R, Montoya-Valverde D, Cedas Ravena PN, Gantenbein Leiva CM, Gonzales Odar MA, Dellacasa J, Aguilar Ruiz Velasco CB, Mejía de Guardado AC, McKeon G, Vancampfort D, Teychenne M, Choudhry U, Baker T, Rosenbaum S.   +17 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Self-Reported Health Literacy and Current Conventional Cigarette Smoking Among Korean Adults: A Cross-Sectional Analysis of the 2024 Korea National Health and Nutrition Examination Survey. [PDF]

Healthcare (Basel)
Kim J, Kwon H.
europepmc   +1 more source

Sample Preparation for Glycoproteins

, 2012
Lam, PY, Liu, X, J. Li, Li, J, Chu, IK, M.P.Y. Lam, Lau, E, X. Liu, E. Lau, I.K. Chu   +9 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Cardiometabolic comorbidity burden and low domain-specific health-promoting lifestyle scores among ethnic minority adults in Yunnan, China: A cross-sectional study. [PDF]

Prev Med Rep
Yu H, Wen S, Li H, Zhao L, Tian H, Liu Z, Peng L.   +6 more
europepmc   +1 more source