Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Retracted: Blasting Law of Liquid CO2 Phase Change in Coal Mine Based on Numerical Simulation
International Journal of Analytical Chemistry, 2023 International Journal of Analytical Chemistry
doaj +1 more source
A Mobile Analytical Chemistry Workstation with a C4D Sensor for Rapid Detection of Organophosphates Under Field Conditions. [PDF]
Sensors (Basel)Wang Y +5 more
europepmc +1 more source
Trends and challenges in analytical chemistry for multi-analysis of illicit drugs employing wastewater-based epidemiology. [PDF]
Anal Bioanal Chem, 2023 de Oliveira AFB +2 more
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
International Journal of Analytical Chemistry, 2023 International Journal of Analytical Chemistry
doaj +1 more source
Estrogens and Progestogens in Environmental Waters: Analytical Chemistry and Biosensing Perspectives on Methods, Challenges, and Trends. [PDF]
Anal ChemLalik A +8 more
europepmc +1 more source
Recent trends in (bio)analytical chemistry. [PDF]
Anal Bioanal Chem, 2021 Gauglitz G, Baeumner AJ.
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source