Results 61 to 70 of about 12,604,570 (252)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Comparative Analysis between Fuzzy and Traditional Analytical Hierarchy Process

MATEC Web of Conferences, 2014
Analytic Hierarchy Process (AHP) is one of the techniques commonly used for prioritizing different alternatives, by using complex criteria. In real applications, conventional AHP assumes the expert judgment as it is exact and use crisp number leading to ...
Mulubrhan Freselam, Mokhtar Ainul Akmar, Muhammad Masdi   +2 more
doaj   +1 more source

IMPLEMENTATION OF AHP METHOD IN THE DECISION SUPPORT OF SELECTION OF STUDENT ACHIEVEMENT CASE STUDY: SENIOR HIGH SCHOOL

Jurnal Riset Informatika, 2020
The research to look for excellence that each student has in order to find out students who excel. Through academic and non-academic achievements can be a benchmark for finding the best students.
Ari Puspita, Yuyun Yuningsih, Hilda Amalia, Ade Fitria Lestari   +3 more
doaj   +1 more source

Selecting equipment using a hybrid of AHP and PROMETHEE [PDF]

Management Science Letters, 2013
, Pages 1767-1772 and PDF (194 K)Abstract: Having appropriate technology is an important managerial decision in today’s manufacturing industry and to choose a good technology, we need to consider various alternatives.
Mohammad Sadegh Horri, Porya Moradi
doaj   +1 more source

Aplikasi Fuzzy Analytical Hierarchy Process Dalam Seleksi Karyawan(Studi Kasus: Pemilihan Staf Administrasi Di PT. XYZ) [PDF]

, 2005
Pada makalah ini akan dibahas mengenai masalah pengambilan keputusan untuk memilih karyawan terbaik. Adapun metode yang digunakan adalah metode Fuzzy Analytical Hierarchy Process, sebagai pengembangan dari metode Analytical Hierarchy Process Konvensional,
Denis Fidita Karya, Mardlijah, Mardlijah, Mardlijah Mardlijah, Karya, Denis Fidita   +3 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Quantitative analytical hierarchy process to marketing store location selection

MATEC Web of Conferences, 2018
The selection of Store to market the product is belong to Multi Criteria Decision Making problem. The criteria used have conflict of interest with each other to produce an optimal location.
Harwati, Utami Intan
doaj   +1 more source

Design of Decision Support System Selection of Beach Tourism Object in GunungKidul using Fuzzy AHP Method

IJID (International Journal on Informatics for Development), 2018
The tourism industry is currently one of the important assessments for a certain region. Gunungkidul has a lot of of beach tourism potentials until visitors are confused to choose the right beach.
Yudi Istianto, Bambang Sugiantoro
doaj   +1 more source