Results 141 to 150 of about 703,453 (308)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

From large-scale to micro machining: a review of force prediction models [PDF]

, 2013
In this paper, a reviewof work performed in the area of force modelling in metal cutting processes is presented. Past and present trends are described and criticised to compare their relevance with current requirements.
FROMENTIN, Guillaume, GERMAIN, Dimitri, Bissey-Breton, Stephanie, BISSEY BRETON, Stéphanie, POULACHON, Gerard   +4 more
core  

Natural Frequency Analysis of a Stepped Drill String in Vertical Oil Wells Subjected to Coupled Axial–Torsional–Lateral Vibrations

Energies
Drilling oil and gas wells is a complex process that requires a combination of several parameters to dig into the ground. Inappropriate drilling parameter settings and reaction forces can lead to unwanted vibrations, which can negatively impact the drill
Mohamed Zinelabidine Doghmane
doaj   +1 more source

Analytical Models of Intra- and Extratumoral Cell Interactions at Avascular Stage of Growth in the Presence of Targeted Chemotherapy. [PDF]

Bioengineering (Basel), 2023
Lavrenteva E, Theodoropoulos C, Binns M.
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Numerical and analytical models applied to wheel-rail contact problems

, 2021
Numerical and analytical models applied to wheel-rail contact problemsNumerical and analytical models applied to wheel-rail contact ...
ZANI, NICOLA
core  

Cost-Effectiveness of Anti-retroviral Adherence Interventions for People Living with HIV: A Systematic Review of Decision Analytical Models. [PDF]

Appl Health Econ Health Policy, 2023
Ahmed A, Dujaili JA, Chuah LH, Hashmi FK, Le LK, Khanal S, Awaisu A, Chaiyakunapruk N.   +7 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Analytical energy dissipation models for low power caches

, 1997
We present detailed analytical models for estimating the energy dissipation in conventional caches as well as low energy cache architectures. The analytical models use the run time statistics such as hit/miss counts, fraction of read/write requests and ...
Milind B. Kamble, Kanad Ghose
core   +1 more source

Application of decision analytical models to diabetes in low- and middle-income countries: a systematic review. [PDF]

BMC Health Serv Res, 2022
Twumwaa TE, Justice N, Robert VM, Itamar M.   +3 more
europepmc   +1 more source