Results 31 to 40 of about 1,038 (200)

Application of Analytical Quality by Design (AQbD) approach in in vitro release test (IVRT) method development in the case of semisolid topical formulations [PDF]

Szoleczky Réka
core   +3 more sources

Application of Analytical Quality by Design (AQbD) in Developing Robust Methods for Herbicide Analysis-A Case Study on Metribuzin

International Journal of Pharmaceutical Research and Applications
Analytical Quality by Design (AQbD) applies Quality by Design principles to analytical method development, aiming to design methods that are robust, well-understood, and life cycle managed. Herbicide residue analysis (monitoring active compounds and metabolites in formulations, food, soil, and water) presents challenges of trace-level detection, matrix
Wafa T Wafa T, Shifa Mammed Kutty K M, Saranya Mohan, Najah P A Meena P V   +3 more
openaire   +2 more sources

Analytical quality by design (AQbD) approach for the simultaneous quantification of FDC in a cardiovascular drug by RP-HPLC method

Future Journal of Pharmaceutical Sciences
Background A sustainable and stability-indicating reversed-phase high-pressure liquid chromatography (RP-HPLC) method has been developed for the simultaneous estimation of chlorthalidone (CHL), Amlodipine (AML), and olmesartan medoxomil (OLM) in a ...
Varsha Thorat, Sudhakar Alave, Vijay Bagul   +2 more
doaj   +2 more sources

Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments. [PDF]

J Mass Spectrom
ABSTRACT The quality control of therapeutic antisense oligonucleotides (ASOs) poses significant analytical challenges due to the complexity of their synthesis and degradation processes and the need to ensure the safety and efficacy of active pharmaceutical ingredients (APIs).
Triolo A, Tavani F, Barnini P, Furlanetto S, Orlandini S.   +4 more
europepmc   +2 more sources

Analytical Quality by Design-Compliant Development of a Cyclodextrin-Modified Micellar ElectroKinetic Chromatography Method for the Determination of Trimecaine and Its Impurities [PDF]

, 2023
In 2022, the International Council for Harmonisation released draft guidelines Q2(R2) and Q14, intending to specify the development and validation activities that should be carried out during the lifespan of an analytical technique addressed to assess ...
Dousa M., Furlanetto S., Gotti R., Jires J., Marzullo L., Nekvapilova P., Orlandini S., Rezanka P., Slavickova P., Zapadlo M.   +9 more
core   +4 more sources

Exploring Analytical Quality by Design (AQbD) Enabled RP-HPLC Method for Carvedilol

Indian Journal of Pharmaceutical Education and Research
Krantisinha Hanumant Randive, Meenaxi Maruti Maste, Amolkumar Ashok Kempwade   +2 more
openaire   +2 more sources

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis [PDF]

Biomed Chromatogr
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Korikana S, Battula S, Konduru N, Kurnool A, Vemuri D, Dantinapalli V.   +5 more
europepmc   +2 more sources

Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation

Pharmaceutics, 2023
Analytical method validation ensures that a method provides trustworthy information about a particular sample when applied in accordance with the predefined protocol. According to regulatory standards, the rheological characteristics of topically applied
Lucas Chiarentin, Catarina Cardoso, Margarida Miranda, Carla Vitorino   +3 more
doaj   +1 more source

Application of quality-by-design approach in the analytical method development for quantification of sugars in sugarcane honey by reversed-phase liquid chromatography [PDF]

, 2020
Produced in Madeira Island from regional sugarcane cultivars through a traditional manufacturing and storage process, sugarcane honey (SCH) is a black syrup recognized by its excellent quality.
Câmara, José S., Nunes, Fernando M., Perestrelo, Rosa, Silva, Catarina L., Silva, Pedro   +4 more
core   +1 more source

Environmental benign RP-HPLC method for the simultaneous estimation of anti-hypertensive drugs using analytical quality by design

Green Chemistry Letters and Reviews, 2023
Green analytical procedures replace harmful organic modifiers with green solvents without affecting chromatographic performance, enabling industries and research laboratories to develop green analytical methods.
Naveenarani Dharuman, Karunanidhi Santhana Lakshmi, Manikandan Krishnan   +2 more
doaj   +1 more source