Results 31 to 40 of about 62,955,482 (158)

Analytical Quality by Design‐Guided Optimisation and Validation of a Short‐Run Stability‐Indicating Reverse‐Phase Ultra‐Fast Liquid Chromatography (RP‐UFLC) Method for the Quantitation of Nonivamide

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT Nonivamide (NON), a capsaicin analogue with similar pharmacological effects, is used in pain management, yet limited information exists on its accurate quantification by reverse‐phase liquid chromatography. A cost‐effective, efficient and precise RP‐HPLC method was developed, optimised using response surface methodology (central composite ...
Phindile Mahlangu, Madan S. Poka, Pedzisai A. Makoni, Bwalya A. Witika   +3 more
wiley   +1 more source

Protein corona characterization through analytical quality-by-design [PDF]

, 2019
Présentation PosterNational audienceAfter administration of nanoparticles (NP) into biological fluids, the NP may interact with surrounding biomolecules like proteins.
Deleforterie, Jeanne, Bastogne, Thierry
core   +1 more source

Analytical Quality by Design (AQbD)-oriented RP-UFLC method for quantification of lansoprazole with superior method robustness

Journal of Liquid Chromatography & Related Technologies, 2017
A reversed-phase ultrafast liquid chromatography method was developed for quantification of lansoprazole in pharmaceutical dosage form using analytical quality by design approach. Systematic planning and experimentation using design of experiment approach were used for method development and optimization studies. A central composite design was used for
Panda, Sagar Suman, Venkata Varaha Ravi Kumar Bera, Sarwar Beg, Omkar Mandal   +3 more
openaire   +1 more source

Sustainable Ethanol‐Based Reversed‐Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics

ChemistryOpen, Volume 15, Issue 5, May 2026.
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Zehra Üstün, İlkay Konçe, Ebru Çubuk Demiralay   +2 more
wiley   +1 more source

Quality by Design Approach for an Orally Disintegrating Tablet Analytical Method Validation

, 2018
Quality by Design (QbD) is well established in the pharmaceutical industry for pharmaceutical development and manufacturing processes. The knowledge obtained during development may support the establishment of a design space and determines suitable ...
B. Yaman, A. Turkyilmaz Yaman, A. Turkyilmaz, G. Demire, D. Saray   +3 more
core   +1 more source

Factorial Design‐Assisted Robustness Testing of an Eco‐Friendly Stability‐Indicating Chromatographic Method for Reliable Ceftazidime Quantification in Injectable Dosage Forms

Journal of Chemistry, Volume 2026, Issue 1, 2026.
A simple, reliable, and environmentally sustainable stability‐indicating chromatographic approach was adopted for the quantitation of ceftazidime in its injectable formulation. The stability‐indicating capability of the approach was confirmed by executing forced degradation under acidic, basic, thermal, oxidative, and photolytic conditions ...
Tahani Y. A. Alanazi, Fahad M. Alminderej, Ammena Y. Binsaleh, Sayed M. Saleh, Mahmoud A. Mohamed, Safa M. Megahed   +5 more
wiley   +1 more source

Application of quality-by-design approach in the analytical method development for quantification of sugars in sugarcane honey by reversed-phase liquid chromatography [PDF]

, 2020
oai:digituma.uma.pt:10400.13/3945Produced in Madeira Island from regional sugarcane cultivars through a traditional manufacturing and storage process, sugarcane honey (SCH) is a black syrup recognized by its excellent quality. Its economic value has led
Silva, Catarina L., Perestrelo, Rosa, Nunes, Fernando M., Silva, Pedro, Câmara, José S.   +4 more
core   +1 more source

Sustainable RP‐HPLC Approach for Profiling Pioglitazone and Related Substances

Journal of Chemistry, Volume 2026, Issue 1, 2026.
A sustainable RP‐HPLC method for the comprehensive fingerprinting of pioglitazone and its related substances was developed and validated in alignment with green analytical chemistry principles. Utilizing eco‐friendly solvents and reducing waste generation were used to optimize chromatographic conditions.
Tahani Y. A. Alanazi, Samar M. Mahgoub, Fahad M. Alminderej, Yasmeen G. Abou El-Reash, Omkulthom Al kamaly, Sayed M. Saleh, Mahmoud A. Mohamed, Munmun Bardhan   +7 more
wiley   +1 more source

Development and Validation of Quality by Design‐Based HPLC Method for Impurity Profiling of Alprazolam

SEPARATION SCIENCE PLUS, Volume 8, Issue 10, October 2025.
ABSTRACT A quality by design (QbD)‐aided stability‐indicating method was developed for the simultaneous quantification of alprazolam and its four impurities using HPLC. The method was systematically optimized, followed by the establishment of a “method operable design region (MODR).” Critical parameters and ICH (Q14) emphasize the adherence to a “low ...
Mahesh Napa, Venkata Ratnam K., Venkata Nadh Ratnakaram, Sunil Dhuri, Bondigalla Ramachandra   +4 more
wiley   +1 more source

Environmental benign RP-HPLC method for the simultaneous estimation of anti-hypertensive drugs using analytical quality by design

, 2023
Green analytical procedures replace harmful organic modifiers with green solvents without affecting chromatographic performance, enabling industries and research laboratories to develop green analytical methods.
Manikandan Krishnan, Karunanidhi Santhana Lakshmi, Naveenarani Dharuman   +2 more
core   +1 more source