Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
An analytical solution for internal forces of shallow circular low-to-vacuum tunnel linings in soft soils. [PDF]
Sci RepShi L, Wang D, Zhang Y, Han F, Lyu Q.
europepmc +1 more source
An Analytical Solution for Stress Transfer between a Broken Prestressing Wire and Mortar Coating in PCCP. [PDF]
Materials (Basel), 2022 Zhang X, Wu J, Hou C, Chen JF.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
An Annular Conductive Membrane-Based Hollow Capacitive Wind Pressure Sensor: Analytical Solution and Numerical Design and Calibration. [PDF]
Materials (Basel)Sun JY, Yan ZQ, Feng HH, He XT.
europepmc +1 more source
Semi-analytical solution for bottomhole pressure transient analysis of a hydraulically fractured horizontal well in a fracture-cavity reservoir. [PDF]
Sci Rep, 2022 Hailong L.
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Analytical solution of nano-concrete-epoxy interaction area considering static equilibrium. [PDF]
Discov NanoHaque MF.
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Analytical Solution and Analysis of Aerodynamic Noise Induced by the Turbulent Flow Interaction of a Plate with Double-Wavelength Bionic Serration Leading Edges. [PDF]
Biomimetics (Basel)Tian C, Liu X, Wang L, Li Y, Wu Y.
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