Results 191 to 200 of about 692,239 (312)

Analytical solution of overlying pipe deformation caused by tunnel excavation based on Pasternak foundation model. [PDF]

Sci Rep, 2023
Fu D, Deng B, Yang M, Zhen B.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analytical solution of seismic power-based equation of motion. [PDF]

Heliyon
Haque MF.
europepmc   +1 more source

Analytical solution of l-i SEIR model-Comparison of l-i SEIR model with conventional SEIR model in simulation of epidemic curves. [PDF]

PLoS One, 2023
Liu X.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Analytical solution of soil deformation caused by vertical pipe jacking construction considering grouting pressure. [PDF]

Sci Rep
Zhou Y, Wei G, Wang X, Tao B, Huang Q, Wei X.   +5 more
europepmc   +1 more source

Analytical solution for nonadiabatic quantum annealing to arbitrary Ising spin Hamiltonian. [PDF]

Nat Commun, 2022
Yan B, Sinitsyn NA.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Range of effectiveness of hydraulic diameter model as an analytical solution for rectangular microchannels. [PDF]

Heliyon
Kobayashi K, Sakamoto K.
europepmc   +1 more source

A New Semi-Analytical Solution for an Arbitrary Hardening Law and Its Application to Tube Hydroforming. [PDF]

Materials (Basel), 2022
Strashnov S, Alexandrov S, Lang L.
europepmc   +1 more source