Results 231 to 240 of about 2,385,497 (271)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

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Coulomb expansion: Analytical solutions

Physical Review E, 2013
Exact and approximate analytical solutions are presented, describing expansion of a cloud of charged particles in one, two, and three dimensions (assuming the planar, axial, and spherical symmetries, respectively). The expansion occurs in a gas or dilute plasma, where the screening is unimportant, so that particles interact with each other via Coulomb ...
openaire   +3 more sources

Analytical Planetary solution VSOP2000

Celestial Mechanics and Dynamical Astronomy, 2001
The analytical planetary solution VSOP2000 determines the planetary perturbations with the help of an iterative method from a solution developed till the third order of the disturbing masses. This solution is from 10 to 100 times more precise than the previous analytical solutions VSOP82 and VSOP87, at the level of some 0.1 mas for Mercury, Venus and ...
Moisson, Xavier, Bretagnon, Pierre
openaire   +2 more sources

Analytic Solutions of Systems

Journal of Dynamical and Control Systems, 2002
The authors present functional series solutions to a nonlinear analytical system for the unknown state variable, and functional series solutions to analytic infinite-dimensional linear systems. Both systems are solved by the SWSE (Summing weighted sequential error) method.
Stefanovski, J., Trenčevski, K.
openaire   +2 more sources

Rational Interpolation: Analytical Solution

Siberian Mathematical Journal, 2001
Summary: The classical problem of interpolation by rational functions is well known to be reduced to a system of linear algebraic equations, but the resultant system is usually complicated for qualitative analysis and numerical implementation. We propose a new approach which generalizes the polynomial interpolation to the rational interpolation both in
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Analytical Solution Methods

2013
This chapter focuses on analytical solutions for the powersplit control problem defined in the previous chapter. Two well known solution concepts will be considered: the method of Lagrange multipliers and Pontryagin’s Minimum Principle. Both concepts have in common that they obtain the necessary conditions for an optimal solution by evaluating where ...
Bram de Jager, Thijs van Keulen, John Kessels   +2 more
openaire   +1 more source

Poroelastic-plastic consolidation — analytical solution

International Journal for Numerical and Analytical Methods in Geomechanics, 1999
Consolidation of a poroelastic material that yields according to Drucker-Prager or Mohr-Coulomb criterion leads to a Stefan problem for time-dependent pore fluid pressure. The solution to the Stefan problem for a column of infinite depth is known and is here adapted to poroelastic/plastic consolidation of a weightless material under a uniform surface ...
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Analytical Methods Of Solution

1969
The theory developed in the previous chapters shows that the study of the linearized Boltzmann equation is a worthwhile undertaking and that many of the features of its solutions can be retained by using model equations. We can say more, that practically all the features are retained by a properly chosen model.
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