Results 231 to 240 of about 2,400,137 (292)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

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Coulomb expansion: Analytical solutions

Physical Review E, 2013
Exact and approximate analytical solutions are presented, describing expansion of a cloud of charged particles in one, two, and three dimensions (assuming the planar, axial, and spherical symmetries, respectively). The expansion occurs in a gas or dilute plasma, where the screening is unimportant, so that particles interact with each other via Coulomb ...
openaire   +3 more sources

Analytical Planetary solution VSOP2000

Celestial Mechanics and Dynamical Astronomy, 2001
The analytical planetary solution VSOP2000 determines the planetary perturbations with the help of an iterative method from a solution developed till the third order of the disturbing masses. This solution is from 10 to 100 times more precise than the previous analytical solutions VSOP82 and VSOP87, at the level of some 0.1 mas for Mercury, Venus and ...
Moisson, Xavier, Bretagnon, Pierre
openaire   +2 more sources

Analytic Solutions of Systems

Journal of Dynamical and Control Systems, 2002
The authors present functional series solutions to a nonlinear analytical system for the unknown state variable, and functional series solutions to analytic infinite-dimensional linear systems. Both systems are solved by the SWSE (Summing weighted sequential error) method.
Stefanovski, J., Trenčevski, K.
openaire   +2 more sources

Rational Interpolation: Analytical Solution

Siberian Mathematical Journal, 2001
Summary: The classical problem of interpolation by rational functions is well known to be reduced to a system of linear algebraic equations, but the resultant system is usually complicated for qualitative analysis and numerical implementation. We propose a new approach which generalizes the polynomial interpolation to the rational interpolation both in
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Analytical Solution Methods

2013
This chapter focuses on analytical solutions for the powersplit control problem defined in the previous chapter. Two well known solution concepts will be considered: the method of Lagrange multipliers and Pontryagin’s Minimum Principle. Both concepts have in common that they obtain the necessary conditions for an optimal solution by evaluating where ...
Bram de Jager, Thijs van Keulen, John Kessels   +2 more
openaire   +1 more source

Poroelastic-plastic consolidation — analytical solution

International Journal for Numerical and Analytical Methods in Geomechanics, 1999
Consolidation of a poroelastic material that yields according to Drucker-Prager or Mohr-Coulomb criterion leads to a Stefan problem for time-dependent pore fluid pressure. The solution to the Stefan problem for a column of infinite depth is known and is here adapted to poroelastic/plastic consolidation of a weightless material under a uniform surface ...
openaire   +2 more sources