Results 61 to 70 of about 3,670 (211)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Безопасность информационных технологийThe paper considers the concept of an intelligent proactive monitoring system for Security Operations Centers (SOC) based on the integration of traditional Security Information and Event Management platforms, machine learning methods, and large language ...
Ivan O. Prokhorets +2 more
doaj +1 more source
Wetting boundary condition for the color-gradient lattice Boltzmann method: Validation with analytical and experimental data [PDF]
, 2018 In the color gradient lattice Boltzmann model (CG-LBM), a fictitious-density wetting boundary condition has been widely used because of its ease of implementation. However, as we show, this may lead to inaccurate results in some cases.
Takashi Akai +5 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2020 The article deals with the task of designing aircraft honeycomb sandwich floor panels considering experimental data on the mechanical properties of new high-strength low-combustible composite materials.
V. A. Komarov +3 more
doaj +1 more source
Characterisation of electrospray properties in high vacuum with a view to application in colloid thruster technology [PDF]
, 2005 PhDThe operational environment of colloid thrusters is high vacuum (10-3 _ 10-6 mbar) however, much of the experimental data collected to date to identify parameter relationships in cone jet mode electrosprays (ES), such as current-volumetric flow ...
Smith, Katharine Lucy
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Ground Effect Influence on UAV Propeller Thrust: Experimental and CFD Validation
TechnologiesThis work investigates the influence of ground effect on the performance of a UAV propeller through a combined experimental, analytical, and numerical approach.
Mădălin Dombrovschi +4 more
doaj +1 more source
Analytical and experimental investigations into fibre/matrix sandwich beams and columns. [PDF]
, 2018 The sandwich construction is a relatively light weight but stiff system which can be manufactured from a large variety of materials. The aircraft and transportation industries are probably the greatest end users of this form of construction.
Lewis, Hana Admon.
core +1 more source