Results 91 to 100 of about 2,122,180 (273)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Laboratory capture, isolation and analysis of microparticles in aerogel: Preparation for the return of Stardust [PDF]
, 2001 We present observations from the laboratory capture of particles in aerogel. The paper focuses on a possible extraction technique and the bulk mineral characterization of the captured material using non-destructive analytical ...
Bland, P.A. +10 more
core
Pharmacological and analytical aspects of artemisinin for malaria: Advances and challenges
Asian Pacific Journal of Tropical Medicine, 2019 Malaria remains a major tropical health burden owing to the development of resistance and decreased sensitivity to the frequently used conventional antimalarial drugs.
Sravani Karri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
MathematicsNew types of truncated M-fractional wave solitons to the simplified Modified Camassa–Holm model, a mathematical physics model, are obtained. This model is used to explain the unidirectional propagation of shallow water waves.
Abdulrahman Alomair +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Integrating explanation-based and empirical learning methods in OCCAM [PDF]
, 1988 This paper discusses an approach to integrating empirical and explanation based learning techniques. The paper focuses on OCCAM, a program that has the capability to acquire via empirical means the knowledge needed for analytical learning.
Pazzani, Michael J.
core
Electromagnetic surface states in structured perfect-conductor surfaces
, 2005 Surface-bound modes in metamaterials forged by drilling periodic hole arrays in perfect-conductor surfaces are investigated by means of both analytical techniques and rigorous numerical solution of Maxwell's equations.
F. J. García de Abajo +4 more
core +1 more source
Concentration of polycyclic aromatic hydrocarbons in roasted coffee beans: a systematic review
Beverage Plant ResearchCoffee is one of the most popular beverages worldwide, and its consumption continues to rise. Coffee beans can be sold as roasted coffee or as green beans.
Kiandokht Ghanati +6 more
doaj +1 more source