Results 71 to 80 of about 536,340 (317)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Viewing an alpine environment positively affects emotional analytics in patients with somatoform, depressive and anxiety disorders as well as in healthy controls [PDF]

open access: gold, 2020
Katharina Hüfner   +6 more
openalex   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

New Insight on Damped Oscillating Regular Structures from “Effective” Proton Electromagnetic Form Factor Data

open access: yesAppliedMath
An objective existence of damped oscillation regular structures from the proton “effective” electromagnetic form factor data, appearing when these data are described by a two parametric Tomasi-Gustafsson-Rekalo function, is investigated. If the same data
Stanislav Dubnička   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Logicism Revisited

open access: yesPrincipia: An International Journal of Epistemology, 2001
In this paper, I develop a new defense of logicism: one that combines logicism and nominalism. First, I defend the logicist approach from recent criticisms; in particular from the charge that a crucial principle in the logicist reconstruction of ...
Otávio Bueno
doaj  

IBM’s Health Analytics and Clinical Decision Support [PDF]

open access: bronze, 2014
Jimeng Sun   +7 more
openalex   +1 more source

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