Results 91 to 100 of about 536,340 (317)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Compact Resolutions and Analyticity
MathematicsWe consider the large class G of locally convex spaces that includes, among others, the classes of (DF)-spaces and (LF)-spaces. For a space E in class G we have characterized that a subspace Y of (E,σ(E,E′)), endowed with the induced topology, is ...
Salvador López-Alfonso +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Putting the Bite Back into "Two Dogmas"
Principia: An International Journal of Epistemology, 2003 Recent Carnap scholarship suggests that the received view of the Carnap-Quine analyticity debate is importantly mistaken. It has been suggested that Carnap’s analyticity distinction is immune from Quine’s criticisms.
Paul A. Gregory
doaj
Journal of Applied MathematicsWe investigate the initial value problem associated to the higher order nonlinear Schrödinger equation i∂tu+−1j+1∂x2ju=u2ju x,t≠0∈ℝ,ux,0=u0x, where j≥2 is any integer, u is a complex valued function, and the initial data u0 is real analytic on ℝ and has ...
Tegegne Getachew +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source