Results 41 to 50 of about 1,783 (122)

Ill-posedness of the hydrostatic Euler and singular Vlasov equations

, 2016
In this paper, we develop an abstract framework to establish ill-posedness in the sense of Hadamard for some nonlocal PDEs displaying unbounded unstable spectra.
Han-Kwan, Daniel, Nguyen, Toan T.
core   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Attracting Manifold for a Viscous Topology Transition

, 1995
An analytical method is developed describing the approach to a finite-time singularity associated with collapse of a narrow fluid layer in an unstable Hele-Shaw flow.
A. L. Bertozzi, A. Pumir, Adriana I. Pesci, B. I. Shraiman, D. W. Moore, G. Tryggvason, H. A. Stone, J. Eggers, J. Eggers, J. R. King, M. A. Lewis, M. C. Cross, M. D. Kruskal, M. P. Brenner, M. Tjahjadi, Michael J. Shelley, P. Constantin, P. Constantin, P. Constantin, R. E. Goldstein, R. E. Goldstein, Raymond E. Goldstein, S. Cardoso, S. H. Davis, S. Tanveer, T. F. Dupont, T. Y. Hou, W. Magnus, W. S. Rayleigh, X. D. Shi   +29 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Advection‐Pressure Splitting Schemes Applied to a Non‐Conservative 1D Blood Flow Model With Transport for Arteries and Veins

International Journal for Numerical Methods in Fluids, EarlyView.
We introduce new efficient and accurate first order finite volume‐type numerical schemes, for the non‐conservative one‐dimensional blood flow equations with transport, taking into account different velocity profiles. The framework is the flux‐vector splitting approach of Toro and Vázquez‐Cendón (2012), that splits the system in two subsystems of PDEs ...
Alessandra Spilimbergo, Eleuterio F. Toro, Annunziato Siviglia, Lucas O. Müller   +3 more
wiley   +1 more source

Impact of Uncertain Parameters on Navier–Stokes Equations With Heat Transfer via Polynomial Chaos Expansion

International Journal for Numerical Methods in Fluids, EarlyView.
This study investigates the impact of uncertain parameters on Navier–Stokes equations coupled with heat transfer using the Intrusive Polynomial Chaos Method (IPCM). Sensitivity equations are formulated for key input parameters, such as viscosity and thermal diffusivity, and solved numerically using the Finite Element‐Volume method.
N. Nouaime, B. Després, M. A. Puscas, C. Fiorini   +3 more
wiley   +1 more source

Initial-Boundary Value Problems for Linear and Soliton PDEs

, 2002
Evolution PDEs for dispersive waves are considered in both linear and nonlinear integrable cases, and initial-boundary value problems associated with them are formulated in spectral space.
Degasperis, A., Manakov, S. V., Santini, P. M.   +2 more
core   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Coping Practices of Small‐ and Medium‐Sized Enterprises Facing Power Asymmetry in Digital Platform Business

Strategic Change, EarlyView.
ABSTRACT Digital platform (DP) enterprises have risen to the top of the global economy by inverting traditional business models. They earn money through matchmaking, transaction facilitation, and efficient orchestration of other stakeholders' resources.
Lukas R. G. Fitz, Jochen Scheeg
wiley   +1 more source