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BCL-3 overexpression in anaplastic lymphoma kinase–positive anaplastic large cell lymphoma
Blood, 2003We read with interest the article by Nishikori et al,[1][1] which reported that expression levels of the bcl-3 gene product distinguish anaplastic lymphoma kinase (ALK)–positive anaplastic large cell lymphoma (ALCL) from Hodgkin lymphoma (HL).
George Z, Rassidakis +2 more
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Inhibitors of the anaplastic lymphoma kinase
Expert Opinion on Investigational Drugs, 2012Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase normally expressed in the developing nervous tissue. Genetic alterations of ALK are associated with a number of cancers, including anaplastic large cell lymphoma (ALCL) and a subset of non-small cell lung cancer (NSCLC).
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Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK)
Journal of Medicinal Chemistry, 2019As a receptor tyrosine kinase of insulin receptor (IR) subfamily, anaplastic lymphoma kinase (ALK) has been validated to play important roles in various cancers, especially anaplastic large cell lymphoma (ALCL), nonsmall cell lung cancer (NSCLC), and neuroblastomas.
Xiaotian Kong +6 more
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Primary leptomeningeal anaplastic T-cell lymphoma, anaplastic lymphoma kinase (ALK) positive
Clinical History: 27-year-old male with a 3-month history of 15 kg weight loss and new-onset focal to generalised tonic seizure. Neurological exam showed right hemiparesis and cranial nerve VII palsy.openaire +1 more source