Results 61 to 70 of about 508,939 (305)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Perception of laboratory management and quality improvement concepts of Saudi anatomic pathology residents and graduates: Venues for improvement

Journal of Family and Community Medicine
: BACKGROUND: Laboratory management and quality improvement (LMQI) is a fundamental nondiagnostic skill for the daily practice of pathologists. Studies recognized a knowledge gap in LMQI in postgraduate training programs with non-uniform outcomes ...
Amal A. Alodaini, Nida M. Khan, Zahra F. Alkhunaizy   +2 more
doaj   +1 more source

Relationship Between the Foveal Avascular Zone and Foveal Pit Morphology [PDF]

, 2012
Purpose.To assess the relationship between foveal pit morphology and size of the foveal avascular zone (FAZ). Methods. Forty-two subjects were recruited.
Beringer, Joseph, Carroll, Joseph, Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Hansen, Benjamin R.   +5 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Anatomic Fat Depots and Coronary Plaque Among Human Immunodeficiency Virus-Infected and Uninfected Men in the Multicenter AIDS Cohort Study. [PDF]

, 2016
Methods.  In a cross-sectional substudy of the Multicenter AIDS Cohort Study, noncontrast cardiac computed tomography (CT) scanning for coronary artery calcium (CAC) scoring was performed on all men, and, for men with normal renal function, coronary CT ...
Brown, Todd T, Budoff, Matthew, Jacobson, Lisa P, Kingsley, Lawrence, Li, Xiuhong, McKibben, Rebeccah, Palella, Frank J, Post, Wendy S, Witt, Mallory D   +8 more
core   +1 more source

MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]

, 2016
PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet, Avni, Reut, Biton, Inbal, Cohen, Yonni, Garbow, Joel R, Golani, Ofra, Neeman, Michael   +6 more
core   +2 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Impact of femoral component design on periprosthetic fracture risk in total hip arthroplasty: ten to 15-year follow-up of composite beam and polished taper slip components

Bone & Joint Open
Aims: Postoperative periprosthetic femoral fractures (POPFF) are a recognized complication following total hip arthroplasty (THA). The primary aim of this study was to compare the survivorship and POPFF rate of a composite beam (CB) femoral component ...
Gareth S. Turnbull, Bin Chen, Muhammad A. Akhtar, Edward Dunstan, Chloe E.H. Scott, James A. Ballantyne, Nick D. Clement   +6 more
doaj   +1 more source