Results 1 to 10 of about 12,044,503 (300)

Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells

open access: yesBiology, 2023
Neural stem cell (NSC) transplantation creates new hope for the treatment of neurodegenerative disorders by direct differentiation into neurons. However, this technique is limited by poor survival and functional neuron deficiency. In this research study,
Yunqin Wu   +11 more
doaj   +1 more source

Modeling modeling modeling [PDF]

open access: yesSoftware & Systems Modeling, 2010
Model-driven engineering and model-based approaches have permeated all branches of software engineering to the point that it seems that we are using models, as Molière's Monsieur Jourdain was using prose, without knowing it. At the heart of modeling, there is a relation that we establish to represent something by something else. In this paper we review
Muller, Pierre-Alain   +3 more
openaire   +3 more sources

Stability of African swine fever virus genome under different environmental conditions [PDF]

open access: yesVeterinary World, 2023
Background and Aim: African swine fever (ASF), a globally transmitted viral disease caused by ASF virus (ASFV), can severely damage the global trade economy.
Wei Zheng   +8 more
doaj   +1 more source

Generation of hiPSCs with ABO c.767T>C substitution: resulting in splicing variants

open access: yesFrontiers in Genetics, 2023
Introduction: The ABO blood group system has important clinical significance in the safety of blood transfusion and organ transplantation. Numerous ABO variations, especially variations in the splice sites, have been identified to be associated with some
Yinge Jin   +12 more
doaj   +1 more source

CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria

open access: yesScientific Reports, 2021
Phenylketonuria (PKU) is an autosomal recessive inborn error of l-phenylalanine (Phe) metabolism. It is caused by a partial or complete deficiency of the enzyme phenylalanine hydroxylase (PAH), which is necessary for conversion of Phe to tyrosine (Tyr ...
Kuldeep Singh   +21 more
doaj   +1 more source

Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes

open access: yesBMC Biology, 2020
Background Endocrine cells of the zebrafish digestive system play an important role in regulating metabolism and include pancreatic endocrine cells (PECs) clustered in the islets of Langerhans and the enteroendocrine cells (EECs) scattered in the ...
Arnaud Lavergne   +7 more
doaj   +1 more source

Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

open access: yesJournal of Translational Medicine, 2021
The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance.
Beatrice Cavalluzzo   +9 more
doaj   +1 more source

New type of microstrip antenna with ferroelectric layer

open access: yesJournal of Telecommunications and Information Technology, 2001
new type of microstrip antenna is proposed using a voltage-controlled ferroelectric thin tape in the multilayered structure. This paper presents the ferroelectric thin tape, its theoretical analysis and design. The results indicate that this concept has
Józef Models, Yevhen Yashchyshyn
doaj   +1 more source

MODELING MODELING [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 1999
Models are tools; they need to fit both the hand and the task. Presence or absence of a feature such as a pacemaker or a cascade is not in itself good. Or bad. Criteria for model evaluation involve benefit‐cost ratios, with the numerator a function of the range of phenomena explained, goodness of fit, consistency with other nearby models, and ...
openaire   +2 more sources

Modeling Model Slicers [PDF]

open access: yes, 2011
Among model comprehension tools, model slicers are tools that extract a subset from a model, for a specific purpose. Model slicers are tools that let modelers rapidly gather relevant knowledge from large models. However, existing slicers are dedicated to one modeling language. This is an issue when we observe that new domain specific modeling languages
Blouin, Arnaud   +3 more
openaire   +2 more sources

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