Results 31 to 40 of about 5,224,722 (268)

FGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-β/β-catenin pathway

Cell Division, 2019
Background Fibroblast growth factor (FGF) and tumor growth factor-β (TGFβ) have emerged as pivotal regulators during the progression of osteosarcoma (OS).
Shuang-Qing Li, Chao Tu, Lu Wan, Rui-Qi Chen, Zhi-Xi Duan, Xiao-Lei Ren, Zhi-Hong Li   +6 more
doaj   +1 more source

Modeling Documents with Event Model [PDF]

Algorithms, 2015
Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way
Longhui Wang, Guoguang Zhao, Donghong Sun   +2 more
openaire   +3 more sources

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Mandatory preventive vaccines for infectious diseases expressing T-cell epitopes for cancer prevention

Infectious Agents and Cancer
We have previously reported that microorganism-associated antigens (MAAs) share high sequence and conformational homology with tumor-associated antigens (TAAs) as well as T cells cross-react with homologous MAA/TAA pairs.
Concetta Ragone, Angela Mauriello, Beatrice Cavalluzzo, Simona Mangano, Biancamaria Cembrola, Noemi Ciotola, Luigi Buonaguro, Maria Tagliamonte   +7 more
doaj   +1 more source

Models. Models. Models. So What? [PDF]

, 2009
In 1985, in an interview for some then-popular magazine, I was asked when models and model-driven development would become commonplace. "In three years time", I replied confidently. In 1987, I was asked the same question, and my answer remained the same. And 1989. And '91.
openaire   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Generation of human induced pluripotent stem cells carrying albumin-sfGFP reporter

Stem Cell Research
Current methodologies for hepatocyte induction from human induced pluripotent stem cells (hiPSCs) have limited efficacy due to lack of a functional hepatocyte reporter.
Jinling Wang, Di Ye, Shuangpeng Li, Xuan Lu, Yue Chi, Chengcheng Tang, Xiaoqing Zhou, Min Chen, Yunwen Zheng, Jianyun Ge, Qingjian Zou   +10 more
doaj   +1 more source

Modeling the purposes of models

, 2012
Today, the purpose of a model is often kept implicit. The lack of explicit statements about a model's purpose hinders both its creation and its (re)use. In this paper, we adapt two goal modeling techniques, the Goal-Question-Metric paradigm and KAOS, an intentional modeling language, so that the purpose of a model can be explicitly stated and ...
Jeanneret, Cédric, Glinz, Martin, Baar, Thomas   +2 more
openaire   +2 more sources