Results 121 to 130 of about 1,164,284 (355)

Growing Brains: Co-emergence of Anatomical and Functional Modularity in Recurrent Neural Networks [PDF]

arXiv, 2023
Recurrent neural networks (RNNs) trained on compositional tasks can exhibit functional modularity, in which neurons can be clustered by activity similarity and participation in shared computational subtasks. Unlike brains, these RNNs do not exhibit anatomical modularity, in which functional clustering is correlated with strong recurrent coupling and ...
arxiv  

Encoding Multi-Resolution Brain Networks Using Unsupervised Deep Learning

, 2017
The main goal of this study is to extract a set of brain networks in multiple time-resolutions to analyze the connectivity patterns among the anatomic regions for a given cognitive task.
Alchihabi, Abdullah, Antsaklis, Panos, Gupta, Vijay, Rahnama, Arash, Vural, Fatos T. Yarman   +4 more
core   +1 more source

Creating and Animating Subject‐Specific Anatomical Models [PDF]

Computer Graphics Forum, 2010
Abstract Creating and animating subject‐specific anatomical models is traditionally a difficult process involving medical image segmentation, geometric corrections and the manual definition of kinematic parameters. In this paper, we introduce a novel template morphing algorithm that facilitates three‐dimensional modelling and parameterization of ...
Gilles, Benjamin, Reveret, Lionel, Pai, Dinesh   +2 more
openaire   +6 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A quantitative biomechanical study of positive buttress techniques for femoral neck fractures: a finite element analysis

Chinese Medical Journal, 2019
. Background:. Refractory femoral neck fractures cannot be anatomically reduced by closed traction reduction which may affect fracture healing. We evaluated the biomechanical effects of positive, negative, and anatomic reduction of various degrees of ...
Gang Wang, Bin Wang, Yong Tang, Hui-Lin Yang, Ning-Ning Wang   +4 more
doaj   +1 more source

Individual differences in human path integration abilities correlate with gray matter volume in retrosplenial cortex, hippocampus, and medial prefrontal cortex [PDF]

, 2017
Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures.
Aselcioglu, Irem, Chrastil, Elizabeth R., Hasselmo, Michael E., Sherrill, Katherine R., Stern, Chantal E.   +4 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

An alternative experimental model for training in microsurgery

Revista do Colégio Brasileiro de Cirurgiões
OBJECTIVE: to describe a new model of training in microsurgery with pig spleen after splenectomy performed by undergraduate students of the Discipline of Operative Technique of the UFPR Medical School.
Ivan Maluf Junior, Alfredo Benjamin Duarte Da Silva, Anne Karoline Groth, Marlon Augusto Camara Lopes, Adriana Sayuri Kurogi, Renato Da Silva Freitas, Flávio Daniel Saavedra Tomasich   +6 more
doaj   +1 more source