Results 51 to 60 of about 97,324 (243)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Low-Cost, High-Fidelity Ultrasound Phantom Gels for Regional Anesthesia Training Programs
MedEdPORTAL, 2012 This module details the construction of low-cost, high-fidelity phantom gels that can be inexpensively produced and reused. These gels mimic the anatomic structures pertinent to performance of upper and lower extremity peripheral nerve blockade under ...
Loreto Lollo, Agnes R. Stogicza
doaj +1 more source
3D printing and urology: Review of the clinical applications
Український Журнал Нефрології та Діалізу, 2020 Three-dimensional (3D) printing is a process that translates a 3D virtual model into its physical 3D replica. In medicine, Neurosurgery, Orthopedics and Maxillo-facial surgery were the first specialties to successfully incorporate this technology in ...
K. Wendo, R. Olszewski
doaj +1 more source
Adaptive Cross‐sections of Anatomical Models
Computer Graphics Forum, 2012 AbstractMedical illustrations have been used for a long time for teaching and communicating information for diagnosis or surgery planning. Illustrative visualization systems create methods and tools that adapt traditional illustration techniques to enhance the result of renderings.
Díaz Iriberri, José +3 more
openaire +3 more sources
Anatomical Models: a Digital Revolution [PDF]
Medical Science Educator, 2015 The use of three-dimensional (3D) anatomical models is ubiquitous in medical education. Medical educators rely on models to depict anatomical structures in a more efficient format than the cadaver; to move away from the clutter, discomfort, and complexity of a cadaveric dissection; and to clarify characteristics or functions of an anatomical structure ...
Fredieu, John R. +4 more
openaire +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC). [PDF]
PLoS ONE, 2015 Perhaps the greatest challenge currently facing the biomedical research community is the ability to integrate highly detailed cellular and molecular mechanisms to represent clinical disease states as a pathway to engineer effective therapeutics.
Robert Chase Cockrell +3 more
doaj +1 more source