Results 61 to 70 of about 182,427 (328)

Anatomic brain asymmetry in vervet monkeys. [PDF]

, 2011
Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance.
Abaryan, Zvart, Cantor, Rita M, Fairbanks, Lynn A, Fears, Scott C, Freimer, Nelson B, Jorgensen, Matthew J, Lee, Chris, Scheibel, Kevin, Service, Susan K, Woods, Roger P   +9 more
core   +1 more source

Genetic diversity in the env V1-V2 region of proviral quasispecies from long-term controller MHC-typed cynomolgus macaques infected with SHIVSF162P4cy [PDF]

, 2018
Intra-host evolution of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) has been shown by viral RNA analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers.
Borsetti, Alessandra, Capone, Alessia, Cella, Eleonora, Ciccozzi, Massimo, Ensoli, Barbara, Farcomeni, Stefania, Ferrantelli, Flavia, Lo Presti, Alessandra, Maggiorella, Maria T, Mee, Edward T, Rose, Nicola J, Sernicola, Leonardo   +11 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Determining the optimum high-flow nasal cannula flow rate to achieve the desired fraction of inspired oxygen: A bench study

Journal of the Formosan Medical Association
Background: Purpose: High-flow nasal cannula (HFNC) has many benefits in various clinical conditions. The original hypothesis suggests that the high and constant fraction of inspired oxygen (FiO2) is one of the main physiological effects.
Chao-Lan Huang, Chun-Ching Lu, Cheng Chiang, Heng-Sheng Chao, Ting-Yun Chiang, Wei-Nung Teng, Wen-Kuei Chang, Chien-Kun Ting   +7 more
doaj   +1 more source

Visualization of back pain data-A 3-D solution [PDF]

, 2007
Traditional approaches to gathering and visualizing pain data rely on two-dimensional (2-D) human body models, where different types of sensation are recorded with various monochrome symbols.
Chana, G, Frank, AO, Ghinea, G, Kent, S
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Emerging technologies to create inducible and genetically defined porcine cancer models

Frontiers in Genetics, 2016
There is an emerging need for new animal models that address unmet translational cancer research requirements. Transgenic porcine models provide an exceptional opportunity due to their genetic, anatomic and physiological similarities with humans.
Lawrence B Schook, Lawrence B Schook, Laurie A. Rund, Karine eBegnini, Mariana Härter Remião, Fabiana Kommling Seixas, Tiago V. Collares   +6 more
doaj   +1 more source

Determination of Face and Content Validity of Cadaveric Model for Holmium Anatomic Endoscopic Enucleation of the Prostate Training: An ESUT AEEP Group Study

European Urology Open Science, 2021
Background: Bench and virtual reality nonbiological simulator models for anatomic endoscopic enucleation of the prostate (AEEP) surgery have been reported in the literature. These models are acceptable but have limited practical applications.
Lutfi Tunc, Giorgio Bozzini, Cesare Marco Scoffone, Selcuk Guven, Thomas Hermann, Angelo Porreca, Vincent Misrai, Sascha Ahyai, Murat Zor, Emin Aksoy, Ali S. Gozen   +10 more
doaj   +1 more source

Bringing Anatomical Information into Neuronal Network Models

, 2021
For constructing neuronal network models computational neuroscientists have access to wide-ranging anatomical data that nevertheless tend to cover only a fraction of the parameters to be determined. Finding and interpreting the most relevant data, estimating missing values, and combining the data and estimates from various sources into a coherent whole
van Albada, Sacha, Morales-Gregorio, Aitor, Bakker, Rembrandt, Palm, Günther, Goulas, Alexandros, Bludau, Sebastian, Dickscheid, Timo, Hilgetag, Claus-Christian, Diesmann, Markus   +8 more
openaire   +5 more sources